To compare the effect of ropivacaine 0.75% nebulization on hemodynamic surge response to intubation and extubation in patients needing surgery under general anaesthesia
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2019/06/019574
- Lead Sponsor
- MIDNAPORE MEDICAL COLLEGE AND HOSPITA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 94
Patients having ASA physical status I & II
Patients of either sex
Patients aged between 18 to 60 years
Elective surgery less than or equal to 3 hours under general anaesthesia
Patientââ?¬•s refusal.
Patients with difficult airway
Patients who are allergic to any of the test drugs
Patients with severe cardiovascular, respiratory, hepatic or renal dysfunction
Recent history of respiratory tract infection
History of chronic smoking
Patients posted for emergency surgery.
Patients with history of alcohol or drug abuse.
Patients with more than one attempt of intubation.
Duration of laryngoscopy and intubation >30 s
Unexpected difficulty in ventilation or intubation
Laryngospasm or bronchospasm occurrence
Time span from completion of nebulization to intubation >20 mins
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Compare the hemodynamic responses during intubation <br/ ><br> <br/ ><br>2.Compare the hemodynamic response during extubation and grade of post extubation cough. <br/ ><br>Timepoint: Hemodynamic response by measuring MAP, SBP, DBP, HR, SpO2 and EtCO2 <br/ ><br> <br/ ><br>Post extubation cough by a score of mild moderate and severe
- Secondary Outcome Measures
Name Time Method 1.Time to extubation (Time from anaesthetic withdrawal to the removal of endotracheal tube) <br/ ><br> <br/ ><br>2.Post-operative sore throat (POST) <br/ ><br> <br/ ><br>3.Agitation during recovery (Ramsey Sedation Score) <br/ ><br> <br/ ><br>4.Nausea and vomiting, <br/ ><br> <br/ ><br>5.Other complications <br/ ><br>Timepoint: POST by Grade 0,1,2,3 <br/ ><br>Pain by VAS