Mild traumatic brain injury biomarker study, a prospective cohort biomarker study of military and civilian participants with mild traumatic brain injury (mTBI-Predict)

niversity of Birmingham0 个研究点目标入组 710 人开始时间: 2023年8月21日最近更新: 2023年9月18日

试验速览

暂无简介。

•Main study:
•1. Aged =18 and =60 years
•2. mTBI: acute (<3 months) mild traumatic brain injury (as per VA/DoD criteria)
•Healthy controls:
•1. Aged =18 years and =60 years
•2. Healthy (screened through NHS General Health Questionnaire)

•Main study:
•1. Prior diagnosis of PTSD or severe mental illness (e.g. bipolar disorder or psychosis)
•2. Pregnancy
•3. Prior brain injury (from trauma, stroke or other aetiologies) without full functional and symptomatic recovery
•4. Inability to comply with study schedule or follow-up
•5. Inability to provide informed consent (e.g. due to cognitive impairment)
•6. Any progressive neurodegenerative or neuroinflammatory condition
•7. Alcohol use disorder or drug dependence
•8. Patients with medical conditions that are unstable or untreated
•Healthy controls:
•1. Medical condition requiring treatment or significant past medical history
•2. Prior diagnosis of PTSD or severe mental illness
•3. Pregnancy
•4. Prior brain injury (from trauma, stroke or other aetiologies) without full functional and symptomatic recovery
•5. Inability to comply with study schedule or follow-up
•6. Inability to provide informed consent (e.g. due to cognitive impairment)
•7. Inability to safely enter the MRI environment (for imaging variability and case-control study)
•8. Any progressive neurodegenerative or neuroinflammatory condition
•9. Cardiovascular or cerebrovascular disease or hypertension (no current diagnosis/medication)
•10. Alcohol use disorder or drug dependence
•11. Patients with medical conditions that are unstable or untreated
•12. History of pituitary hormone deficits

发起方