Mild traumatic brain injury biomarker study, a prospective cohort biomarker study of military and civilian participants with mild traumatic brain injury (mTBI-Predict)

niversity of Birmingham0 sites710 target enrollmentAugust 21, 2023

Overview

No summary available.

Registry

who.int

Start Date

August 21, 2023

End Date

November 30, 2029

Last Updated

2 years ago

Study Type

Observational

Sex

All

Sponsor

•Main study:
•1\. Aged \=18 and \=60 years
•2\. mTBI: acute (\<3 months) mild traumatic brain injury (as per VA/DoD criteria)
•Healthy controls:
•1\. Aged \=18 years and \=60 years
•2\. Healthy (screened through NHS General Health Questionnaire)

•Main study:
•1\. Prior diagnosis of PTSD or severe mental illness (e.g. bipolar disorder or psychosis)
•2\. Pregnancy
•3\. Prior brain injury (from trauma, stroke or other aetiologies) without full functional and symptomatic recovery
•4\. Inability to comply with study schedule or follow\-up
•5\. Inability to provide informed consent (e.g. due to cognitive impairment)
•6\. Any progressive neurodegenerative or neuroinflammatory condition
•7\. Alcohol use disorder or drug dependence
•8\. Patients with medical conditions that are unstable or untreated
•Healthy controls: