A Prospective Comparative Study of a Novel Gadolinium-Weighted MRI Sequence Versus Conventional T1-Weighted Imaging for the Detection of Brain Metastases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Difference in Number of Detected Gadolinium-Enhancing Brain Metastases Between the Novel Gadolinium-Weighted MRI Sequence and Conventional T1-Weighted Imaging
研究概览
简要总结
This study will evaluate a new type of MRI sequence designed to improve the visibility of brain metastases after gadolinium contrast injection. The purpose is to determine whether this novel "gadolinium-weighted" imaging method can detect more or smaller tumors than standard MRI techniques. Participants will undergo a routine brain MRI with contrast, followed by an additional scan using the new method. The goal is to improve diagnostic accuracy without increasing the contrast dose or scan time.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Scheduled for clinical brain MRI with gadolinium contrast
- •Known or suspected brain metastases
- •Able to provide informed consent
- •Able to lie still for the duration of the MRI examination
排除标准
- •Contraindications to MRI
- •Known allergy or contraindication to gadolinium-based contrast agents
- •Renal impairment (eGFR < 30 mL/min/1.73m²)
- •Pregnant or breastfeeding
- •Inability to comply with study procedures
研究组 & 干预措施
Patients with Suspected or Known Brain Metastases
Participants undergoing clinically indicated brain MRI with gadolinium contrast who will receive both conventional T1-weighted imaging and the novel gadolinium-weighted MRI sequence during the same scan session. The purpose is to compare lesion detection and conspicuity between the two sequences.
干预措施: Novel Gadolinium-Weighted MRI Sequence (Diagnostic Test)
结局指标
主要结局
Difference in Number of Detected Gadolinium-Enhancing Brain Metastases Between the Novel Gadolinium-Weighted MRI Sequence and Conventional T1-Weighted Imaging
时间窗: At the time of gadolinium-enhanced MRI, during a single imaging session (within 1 hour of contrast administration)
次要结局
未报告次要终点