Evaluation of Pesticide Exposure in the General Population
- Conditions
- Pesticide Poisoning
- Interventions
- Biological: Questionnaire, blood, urine, hair and dust samplings
- Registration Number
- NCT02986763
- Lead Sponsor
- Centre Leon Berard
- Brief Summary
An association has been suggested with several diseases including cancer and IARC has classified several pesticides as carcinogenic, probably carcinogenic. There is a need for a better characterisation of environmental pesticides exposures and identification of suitable biomarkers of exposure and effect. A better understanding of the impact of pesticide exposure on metabolomic, transcriptomic and epigenetic changes, is essential to strengthen epidemiological hypotheses on the association with several cancer types.
The main objective of the project is to validate a GIS (geographic information system) based method to assess environmental pesticide exposures, using environmental (contamination of housedust) and biological (blood and urine samples) measures. The project aims further to investigate a potential link between housedust contamination and biological measures in healthy non-smoking male residents and explore the impact of environmental pesticide exposure on metabolomics, transcriptomic and epigenetic parameters.
- Detailed Description
The project involves a pilot phase involving repeated (twice) sampling in 20 male non-smoking volunteers living in the Beaujolais region (France) to perform appropriate calibrations for metabolomic, transcriptomic and epigenetic analyses. The main study will be conducted in a sample of 150 male non-smoking volunteers and 50 professional pesticides applicators from the same region (3 sampling periods).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 166
- Non smokers in the last two years Living in the Beaujolais region (France) within 1000m of vignards Informed consent signed
- Volunteers sharing the same households with professional applicators of pesticides
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Volunteers Questionnaire, blood, urine, hair and dust samplings Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling Professional pesticides Questionnaire, blood, urine, hair and dust samplings A specific questionnaire with professional information about pesticide uses is added for this arm Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling
- Primary Outcome Measures
Name Time Method level of pesticide exposures up to 2 years environmental, occupational and domestic exposures
- Secondary Outcome Measures
Name Time Method