跳至主要内容
临床试验/NCT00854893
NCT00854893已完成不适用

Enhance of Language Learning with Neurostimulation (transcranial Direct Current Stimulation)

Universitätsklinikum Hamburg-Eppendorf2 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2009年10月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
70
试验地点
2
主要终点
word learning

研究概览

简要总结

The purpose of this study is to test the effect of transcranial direct current stimulation over the motor cortex of the language dominant hemisphere on language learning in healthy subjects and stroke patients with aphasia. We hypothesize that anodal stimulation enhances the learning of action words compared to sham and cathodal stimulation.

详细描述

The motor cortex is involved at different levels of language processing. It has been demonstrated that the perception of action words activates motor representations in the language-dominant hemisphere. However, it is not known whether modulation of excitability has an effect on learning new action words. Thus, we hypothesize that transcranial direct current stimulation over the motor cortex of the language-dominant hemiphere modulates the acquisition of new action words. The results bear the potential to design new rehabilitative strategies in stroke patients with aphasia. The motor cortex might offer an access to the language network that can be used for interventional approaches such as neurostimulation.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Treatment
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 86 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • age >18 and < 86 years
  • contractual capability
  • ischemic stroke excluding motor cortex (stroke patients)
  • minimum time since stroke 9 months
  • aphasia (stroke patients)
  • severe aphasia that impedes understanding of instructions (stroke patients)

排除标准

  • sever head trauma in the past
  • pace maker
  • metal implants in the head/neck region
  • severe comorbidity, especially neurologic and psychiatric diseases
  • intake of illegal drugs
  • Mini Mental State examination score < 27
  • neuroactive substances, e.g. antidepressants
  • pregnancy

结局指标

主要结局

word learning

时间窗: immediately after intervention and after 1 week

learning of new action words measured as learned words/all words in %

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

Loading locations...

相似试验

Enhance of Language Learning with Neurostimulation | 临床试验