A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients
- Conditions
- Gastrointestinal Lymphoma
- Interventions
- Diagnostic Test: Metagenomic shotgun sequencing
- Registration Number
- NCT03930043
- Lead Sponsor
- Ruijin Hospital
- Brief Summary
This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.
- Detailed Description
This observation study is aimed at investigating the gut microbiota alteration in gastrointestinal lymphoma (GIL) patients by performing metagenomic shotgun sequencing on GIL patients' fecal specimen. Before immuno-chemotherapy, the feces specimen of GIL would be collected and stored for further laboratory examination. This study would NOT alter the subsequential treatment of the patients.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
- Gastrointestinal lymphoma with a clarified pathological diagnosis
- De novo gastrointestinal lymphoma patients who haven't received chemotherapy
- BMI in normal range
Exclusion Criteria
- Antibiotics or probiotics application within a month
- Overweight (BMI≥25) or malnourished (BMI<18.5) patients
- Patients who have been accepted gastrointestinal fistulation
- Gastrointestinal patients with inflammatory bowel disease (IBD), colorectal carcinoma (CRC) or any other chronic intestinal disease
- Patients infected by HIV
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Non-gastrointestinal Lymphoma Metagenomic shotgun sequencing - Gastric Lymphoma Metagenomic shotgun sequencing - Health Control Metagenomic shotgun sequencing - Intestinal Lymphoma Metagenomic shotgun sequencing -
- Primary Outcome Measures
Name Time Method Metagenomic Linkage Groups (MLGs) 2 years A serial of genes in a metagenome that is probably physically linked as a microbial unit.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Shanghai Ruijin Hospital
🇨🇳Shanghai, Shanghai, China