NCT03930043Unknown不适用
A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Metagenomic Linkage Groups (MLGs)
研究概览
简要总结
This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.
详细描述
This observation study is aimed at investigating the gut microbiota alteration in gastrointestinal lymphoma (GIL) patients by performing metagenomic shotgun sequencing on GIL patients' fecal specimen. Before immuno-chemotherapy, the feces specimen of GIL would be collected and stored for further laboratory examination. This study would NOT alter the subsequential treatment of the patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Gastrointestinal lymphoma with a clarified pathological diagnosis
- •De novo gastrointestinal lymphoma patients who haven't received chemotherapy
- •BMI in normal range
排除标准
- •Antibiotics or probiotics application within a month
- •Overweight (BMI≥25) or malnourished (BMI<18.5) patients
- •Patients who have been accepted gastrointestinal fistulation
- •Gastrointestinal patients with inflammatory bowel disease (IBD), colorectal carcinoma (CRC) or any other chronic intestinal disease
- •Patients infected by HIV
结局指标
主要结局
Metagenomic Linkage Groups (MLGs)
时间窗: 2 years
A serial of genes in a metagenome that is probably physically linked as a microbial unit.
次要结局
未报告次要终点
研究者
Zhao Weili
Deputy Director of Hematology Department
Ruijin Hospital
研究点 (1)
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