Comparison of Detection and Miss Rates of Blue Laser Imaging Versus Conventional White Light Colonoscopy

Not Applicable

• Conditions: Colorectal Adenoma
• Interventions: Device: blue laser imaging colonoscopy; Device: conventional white light colonoscopy

• Registration Number: NCT02982447
• Lead Sponsor: Yangzhou No.1 People's Hospital

Brief Summary

It is a randomized controlled trial with tandem colonoscopy.Participants were randomized for use of either blue laser imaging or conventional White Light Colonoscopy on withdrawal method.comparison of detection and miss rates of BLI group Versus conventional White Light Colonoscopy.

Detailed Description

blue laser imaging (BLI) are a new imaging systems used in endoscopy which are recently developed. According to three recently published reports, the diagnostic ability of adenoma characterization using blue laser imaging compares favorably with narrow band imaging. No published data are available to date regarding adenoma detection with blue laser imaging.BLI has the possibility to increase the detection of colorectal polyps by sufficient brightness and clearer endoscopic images.The investigators recruited participants who underwent colonoscopy for symptoms,screening,or surveillance.Participants were randomized for use of either blue laser imaging (BLI) or conventional white light colonoscopy on withdrawal method.Lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates,respectively.The primary outcomes is to compare the adenoma and poly detection rates of BLI with conventional white light Colonoscopy.

Study Timeline

• Study First Submitted: 2016-11-19
• Status Verified: 2016-12
• Study Start: 2016-12
• Study First Submitted QC: 2016-12-02
• Last Update Submitted: 2016-12-02
• Study First Posted: 2016-12-05
• Last Update Posted: 2016-12-05
• Primary Completion: 2017-04
• Study Completion: 2017-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 420

Inclusion Criteria

• consecutive patients who were underwent colonoscopy in our center for diagnostic work up of colonic symptoms,surveillance of colorectal polyps, and colorectal cancer screening.

Exclusion Criteria

• history of colon cancer, colectomy familial adenomatous polyposis, or inflammatory bowel diseases;
• severe intestinal stenosis or obstruction;coagulation，disorders;
• pregnancy;
• and colonoscopy examinations with inadequate bowel cleanliness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Blue Laser Imaging colonoscopy	blue laser imaging colonoscopy	Insertion to cecum was performed under white light(WL) and once the cecum was reached, the Blue Laser Imaging mode was switched on during withdrawal of endoscope for complete colonic examination. Second colonoscopic examination was performed in a similar manner after the first complete withdrawal of the colonoscope. WL was used on insertion and WL was used on withdrawal
conventional white light colonoscopy	conventional white light colonoscopy	In this arm, WL was used for both insertion and withdrawal of the colonoscope during the first-pass and second-pass examinations.

Primary Outcome Measures

Name	Time	Method
comparison of colorectal adenoma miss rates of blue laser imaging (BLI) Versus conventional White Light Colonoscopy	6 months
comparison of colorectal adenoma detection rates of blue laser imaging (BLI) Versus conventional White Light Colonoscopy	6 months

Trial Locations

Locations (1)

First people's hospital of yangzhou; 🇨🇳 Yangzhou, Jiangsu, China