NL-OMON53287尚未招募不适用
Brain kinetics of neurotransmission during JWH-018 intoxication - Brain activity under the influence of JWH
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 29
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •* Used cannabis between 1 time a month and 2 times a week during the previous
- •* Age between 18 and 40 years
- •* Free from psychotropic medication
- •* Good physical health as determined by medical examination and laboratory
- •* Absence of any major medical, endocrine and neurological condition as
- •determined by medical examination and laboratory analysis
- •* Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
- •* Written Informed Consent
- •* Good knowledge and understanding of the English language
- •* Participants must be willing to refrain from taking illicit psychoactive
- •substances during the study.
- •* Participants must be willing to drink only alcohol-free liquids and no
- •coffee, black or green tea, or energy drinks after midnight of the evening
- •before the study session, as well as during the study day.
- •* Participants must be willing not to drive a traffic vehicle or to operate
- •machines within 24 h after substance administration.
排除标准
- •* History of drug addiction (determined by the medical questionnaire, drug
- •questionnaire and medical examination). * Pregnancy or lactation or pregnancy
- •planned during study participation. * Hypertension (diastolic > 90 mmHg;
- •systolic > 140 mmHg). * Current or history of psychiatric disorder (determined
- •by the medical questionnaire and medical examination). * Current presence or
- •history of psychosis in first-degree relatives * Any chronic or acute medical
- •condition. * History of cardiac dysfunctions (arrhythmia, ischemic heart
- •disease,*). * For women: no use of a reliable contraceptive. * Tobacco smoking
- •(>20 per day). * Excessive drinking (>20 alcoholic consumptions per week).
- •Furthermore, to participate in MRI scanning a few conditions need to be
- •satisfied by the subject. In the following cases, a MRI scan is not possible: *
- •The subject had an operation to his head or brain. * The subject has implanted
- •electronic devices, like a pacemaker. * The subject has an insulin pump under
- •his skin. * The subject suffers from epilepsy. * The subject suffers from
- •claustrophobia. * The subject has cardiological irregularities. * If there is a
- •chance that the subject might be pregnant. * If, apart from teeth fillings and
- •connectors, there are other metal parts in the body, like: o protheses o
- •implants o clips on blood vessels o metal parts in the eye o spiral o metal
- •braces o other metal objects In the following cases the researcher first needs
- •to establish, in collaboration with the participant, whether it would be
- •possible to have an MRI scan: * Subject has a tattoo (also permanent make-up).
- •* Subject has one or several piercings that cannot be removed. * Subject has a
- •metal wire behind his teeth.
研究者
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