Clinical Study on a Novel Strategy of Individualized Non-Invasive Neuromodulation for the Treatment of Tic Disorders in Children

Shanghai Children's Medical Center0 个研究点目标入组 60 人开始时间: 2025年6月1日最近更新: 2026年1月20日

试验速览

阶段: 不适用
状态: 招募中
发起方
入组人数: 60

研究概览研究设计入排标准研究者记录与标识符相似试验

研究概览

简要总结

This study aims to establish a novel personalized closed-loop NiBS/TMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations. Additionally, it seeks to elucidate the underlying neural circuit mechanisms, enhance the therapeutic efficacy of TMS in pediatric TDs, and achieve precision neuromodulation for children with TDs.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Single (Participant)

入排标准

年龄范围: 5 Months 至 18 Years（Child, Adult）
性别: All
接受健康志愿者: 否

入选标准

•1: Children and adolescents aged 5 to 18 years
•2: Meets DSM-5 diagnostic criteria for Tic Disorders (TDs) with normal EEG findings
•3: No prior treatment received for TDs
•4: Full-scale intelligence quotient (FIQ) ≥70 on the Wechsler Intelligence Scale for Children-Revised (WISC-R)

排除标准

•1: WISC-R Full-Scale Intelligence Quotient (FIQ) <70
•2: Presence of metal implants in the body ，Non-right-handedness
•3: Head movement (HM) >2mm during fMRI scanning, including both translational movement (TM) and rotational movement (RM)
•4: Any other neurological or psychiatric conditions, including but not limited to autism spectrum disorder (ASD), epilepsy, obsessive-compulsive disorder (OCD), etc
•5: Previous head trauma ，Neurological diseases ，Major systemic illnesses

研究者

发起方

Shanghai Children's Medical Center

申办方类型

Other

责任方

Sponsor

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