Association of Gut Microbiota Diversity With Extended-spectrum Beta-lactamase Producing Enterobacteriales Fecal Carriage and Subsequent Infection in Intensive Care Unit: Microbe Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Gut bacteriobiota diversity according to ESBL specie
研究概览
简要总结
Antimicrobial resistance is a major threat worldwide and extended-spectrum beta-lactamase producing Enterobacteriales (ESBL-E) are a leading cause because of their wide dissemination. Gut microbiota seems to be correlated with multi-drug resistant organism carriage. This study thus aims to analyse the correlation between gut microbiota, ESBL-E fecal carriage and subsequent infection.
详细描述
The rising antimicrobial resistance has led to more than 33,000 deaths in Europe in 2015. Among them, extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are the most frequent in Europe and have disseminated both in the community and in healthcare settings. Some studies have suggested that microbiota could be different between multi-drug resistant organisms, with different relative abundances of some bacteria. One study focused on ESBL-E fecal carriers, but in the community, with Bacteroides uniformis being more abundant in ESBL-E non-carriers than carriers. As identification of species discriminating between ESBL-E fecal carriers and non-carriers could pave the way for the design of ESBL-E carriage eliminating probiotics, we aim to analyse the correlation between gut microbiota and ESBL-E fecal carriage.
Moreover, mechanisms in the link between ESBL-E fecal carriage and subsequent ESBL-E infection remain, so far, poorly understood and this study aims to provide a first insight in the involvement of gut microbiota in the link between colonization and infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient above 18 year-old admitted to intensive care unit
- •ESBL-E fecal carriage according to current screening recommendations for ESBL-E carriage group
- •Feces quantity on rectal swab adequate for routine screening and microbiota analysis
排除标准
- •Guardianship, curatorship, or prisoners
- •No health insurance
- •No legal representative
结局指标
主要结局
Gut bacteriobiota diversity according to ESBL specie
时间窗: at positive screening
Comparison of gut bacteriobiota alpha diversity between ESBL E. coli and ESBL K. pneumoniae fecal carriers
次要结局
- Gut mycobiota diversity according to ESBL specie(at positive screening)
- Gut bacteriobiota and subsequent ESBL-E infection(at admission)
- Bacteria and the absence of subsequent ESBL-E infection(at admission)
- Fungi and the absence of subsequent ESBL-E infection(at admission)
- fungi and the absence of ESBL E. coli fecal carriage(at admission)
- Gut bacteriobiota diversity according to ESBL specie(at positive screening)
- fungi and the absence of ESBL K. pneumoniae fecal carriage(at admission)
- bacteria and the absence of ESBL K. pneumoniae fecal carriage(at admission)
- bacteria and the absence of ESBL E. coli fecal carriage(at admission)
- Gut mycobiota and subsequent ESBL-E infection(at admission)
研究者
Dr Pauline Esteves
Doctor
University of Bordeaux