Investigational Use of Neuromuscular Ultrasound
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- To acquire normative values for B-mode imaging of nerves (fascicle count) and muscles (quantitative echotexture measurement) and shear wave elastography data on muscle and nerve stiffness/speed of sound in a population of healthy volunteers.
研究概览
简要总结
Background:
Current techniques used to measure the health and function of a person s nerves and muscles are generally effective, but they do have limits. Researchers are looking for ways to improve the ability to observe nerves and muscles and how they function in this natural history protocol.
Objective:
To study the use of ultrasound (sound waves) to learn more about nerves and muscles.
Eligibility:
Healthy adults, aged 18 and older, with no history of stroke, nerve or muscular disorders, or spine surgery are also needed. A smaller population of adults aged 18 and older who have a neuromuscular disorder or show symptoms of nerve or muscle disorder will also be evaluated.
Design:
Participants will be screened with a medical record review.
Participants will have up to 5 outpatient clinic visits. Most participants will have 1 or 2 visits. Visits will last for less than 3-4 hours each.
During each visit, participants will give a brief medical history and have a physical exam.
Participants will have ultrasounds to get pictures and measurements of their nerves and muscles. Gel will be applied to their skin. A probe will be placed on the skin surface. Sound waves sent through the probe will be used to create pictures.
Participants may have nerve conduction studies. Wires will be taped to the skin surface near a muscle or nerve in the arm or leg. The nerve will be stimulated with a small electric current that feels like a rubber band flick. The response will be recorded through the wires.
详细描述
Study Description:
Currently there are a limited number of biomarkers that can provide quantitative, reliable information about nerve and muscle function and structure in patients with neuromuscular diseases. This protocol aims to investigate and define specific ultrasound imaging techniques of nerves and muscles that may be useful as biomarkers in clinical trials. For nerve studies, we aim to evaluate the use of high resolution ultrasound probes for B-mode imaging including cross sectional area, diameter and nerve fascicle counts. Additional imaging modalities will be evaluated including shear wave elastography and low flow microvascular imaging. Ultrasound modalities for muscle imaging will include B-mode imaging, muscle thickness, echo-intensity and or shear wave imaging and low flow microvascular imaging. The hypothesis for incorporating these ultrasound imaging modalities into neuromuscular evaluations is these techniques can provide unique quantitative, reproducible data about the structure of nerves and muscles. This information can be used to compare patients with controls and measure change in these modalities in neuromuscular disease states and determine if these measures can serve as a reliable biomarker in neuromuscular diseases.
Objectives:
Primary Objectives:
- To acquire normative values for elastography of muscle in a population of healthy volunteers
- To acquire normative values for elastography of nerve in a population of healthy volunteers
- To acquire normative values of nerve fascicular count in a population of healthy volunteers
- To collect normal values of M-mode diaphragm imaging during quiet and deep breathing and voluntary sniff testing in a population of health controls to establish normal values.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 110 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •INCLUSION CRITERIA:
- •In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- •Healthy Volunteers-Adults
- •Healthy adults, male or female, aged 18 years old or older,
- •In good general health as evidenced by medical history, medical conditions under control such as hypertension acceptable.
- •Stated willingness to comply with all study procedures and availability for the duration of the study.
- •Ability of subject to understand and the willingness to sign a written informed consent document.
- •Participants with neuromuscular disorders
- •Adults, male or female, aged 18 years old or older,
- •Diagnosed with a neuromuscular disorder or have signs and symptoms of nerve or muscle disorder or neuromuscular diaphragm dysfunction.
- •Stated willingness to comply with all study procedures and availability for the duration of the study.
- •Ability of subject to understand and the willingness to sign a written informed consent document.
排除标准
- •Healthy Volunteers-Adults
- •History of stroke, muscle disorders, peripheral neuropathy, or spine surgery
- •Participants with neuromuscular disorders
- •No clinical evidence of a neuromuscular disorder on clinical evaluation.
研究组 & 干预措施
Neuromuscular disorders
Diagnosed with a neuromuscular disorder such as motor neuron disorder, myopathy or have findings consistent with a peripheral neuropathy.
Normal volunteers
No known abnormal muscle or nerve disorders
结局指标
主要结局
To acquire normative values for B-mode imaging of nerves (fascicle count) and muscles (quantitative echotexture measurement) and shear wave elastography data on muscle and nerve stiffness/speed of sound in a population of healthy volunteers.
时间窗: ongoing
Normative values for muscle and nerve shear wave elastography in a population of normal volunteers Normative values for nerve fascicular count in a population of normal volunteers
To collect normal values of M-mode diaphragm imaging during quiet and deep breathing and voluntary sniff testing in a population of health controls to establish normal values.
时间窗: ongoing
Normative values for M-mode imaging of the diaphragm in a population of healthy controls.
次要结局
- To determine the presence or absence of low flow microvascular flow within nerves of a population of healthy volunteers(ongoing)
- To determine the reproducibility of specialized techniques involving ultrasound of muscle and nerve: shear wave elastography in muscles and nerves, nerve fascicle counts(ongoing)