EFFICACY OF GREEN TEA CATECHIN GEL LOCAL DRUG DELIVERY IN THE MANAGEMENT OF CHRONIC PERIODONTITIS PATIENTS
Phase 3
Completed
- Conditions
- Health Condition 1: null- CHRONIC PERIODONTITIS
- Registration Number
- CTRI/2014/08/004925
- Lead Sponsor
- PMS COLLEGE OF DENTAL SCIENCE AND RESEARCH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Systemically healthy patients diagnosed with generalised or localised chronic periodontitis
More than three natural teeth each quadrant
Probing pocket depth >= 5 mm in a minimum of one site each in two quadrants of the same arch
Radiographic evidence of bone loss in sites with probing pocket depth >5 mm.
Those willing to participate in the study
Exclusion Criteria
History of antibiotics in last 6 months
History of periodontal therapy in last 6 months
Psychological disorders
Aggressive periodontitis
Current smokers
Immunocompromised patient
Pregnant and lactating females
Blood disorders
Any other contraindication for periodontal surgery
Diabetes
Any other systemic disorders
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in inflammation of periodontal tissues as measured by bleeding on probing, probing pocket depth, clinical attachment loss and gingival recession is expected to be significantly more in green tea catechin site compared to the placebo groupTimepoint: reevaluation at 11/2,3,6,9 months
- Secondary Outcome Measures
Name Time Method Decrease in the need for surgical treatment in the test sites. <br/ ><br>Expression of MMP 9 in green tea catechin administered site is expected to be less compared to the expression in control site. <br/ ><br>Radiographic bone fill in green tea catechin administered pockets is expected to be more than the pockets in control site <br/ ><br>Timepoint: Decrease in the need for surgical treatment in the test sites after 11/2 months <br/ ><br>Expression of MMP 9 in test and control sites assessed at the time of surgery after 11/2 months <br/ ><br>Radiographic bone fill in test and control sites after 9 months <br/ ><br>