Risk Prediction and Therapy Monitoring in Patients With SARS-Cov-2 Infection / COVID 19
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- D5-20
研究概览
简要总结
Approximately 15% of patients with SARS-CoV-2 infection / COVID-19 develop a severe clinical course. This leads to hospitalization and potentially life threatening complications such as pneumonia and respiratory failure. Predictors for early detection and risk stratification are urgently needed. Moreover, only scarce information is available for long-term follow-up and late complications associated with infection. We therefore aimed to find predictors for severe courses of the novel disease as well as to establish strategies for therapeutic monitoring and follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SARS-CoV-2 infection / COVID 19
排除标准
- •invasive ventilation
- •respiratory failure at admission
结局指标
主要结局
D5-20
时间窗: 1-6 months (outpatients, follow up)
frequency dependence of resistance as measured by oscillometry
FEV1/FVC
时间窗: 1-6 months (outpatients, follow up)
forced expiratory volume in 1 s / forced vital capacity (as measured by spirometry)
TLCO
时间窗: 1-6 months (outpatients, follow up)
Transfer factor for carbon monoxide
次要结局
- comorbidities(at hospital admission and each follow (every 1-6 months))
- clinical symptoms(3-5 days intervals (inpatients), 1-6 months (outpatients, follow up))
- St. George's Respiratory Questionnaire total score(3-5 days intervals (inpatients), 1-6 months (outpatients, follow up))
研究者
Dr. Frederik Trinkmann
Principal Investigator
Heidelberg University