DRKS00000942已完成不适用
A European treatment protocol for bonesarcomain patients older than 40 years (EURO-B.O.S.S.) - Euro-B.O.S.S.
Klinikum Stuttgart0 个研究点目标入组 135 人开始时间: 2015年3月19日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 135
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40 Years 至 65 Years（—）
- 性别
- All
入选标准
- •1. Histologically proven diagnosis of high-grade sarcoma of bone of any site.
- •2. Histologic types: osteosarcoma (high-grade surface, central primary and secondary),
- •fibrosarcoma, malignant fibrous histiocytoma, leiomyosarcoma, dedifferentiated chondrosarcoma,
- •angiosarcoma.
- •EUROpean Bone Over 40 Sarcoma Study EURO-B.O.S.S. Version_2.0 COSS Dec 2009 13/24
- •3. Age: 41 - 65
- •4. Normal bone marrow, hepatic, cardiac and renal function
- •5. Absence of contraindications to the use of cisplatin, adriamycin (doxorubicin), and ifosfamide
- •6. Written informed consent
排除标准
- •1. Planned chemotherapy and/or follow-up not feasible
- •2. Previous chemotherapy treatment, which contraindicates the use of one or more drugs, included
- •in the present procol
- •3. Previous chemotherapy treatment for the current tumor
- •4. White blood count < 3.0 x 109/L, and platelets < 100 x 109/L
- •5. Creatinine clearance < 70 ml/min
- •6. Left ventricular ejection fraction < 55% or fractional shortening rate of the left ventricle <28%
- •7. Serum transaminases and bilirubin > 2 times the normal values
- •8. ECOG performance status > 2
- •9. Chondrosarcoma or small/round cell bone sarcoma including mesenchymal chondrosarcoma and
- •Ewing’s family tumors.
- •10. Pregnancy
研究者
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