Time course of platelet reactivity in the acute phase of STEMI as measured with various platelet function studies - TOPS

Sint Antonius Ziekenhuis0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Patient must meet ALL of the following criteria:
•Males or females > 21 years of age and < 85 years with symptoms of acute myocardial infarction of more than 30 minutes but less than 12 hours.
•ST segment elevation of > 1 mV in 2 adjacent ECG leads, with cumulative ST- segment deviation of 6 mm or more.
•Patients should only be included if there is a reasonable expectation that PCI will be conducted within 1 hour.

•1) Patients who are unable to give informed consent or have life expectancy of < 1year
•2) Subjects who have received thrombolytic therapy within 24 hours before PCI or GpIIb/IIIa-inhibitors within the last 15 days or during the PCI
•3) Subjects with a contra-indication to anticoagulation or at increased bleeding risk
•a. Past or present history (<1 year) of bleeding from gastrointestinal (haematemesis) melena, frank bleed in stool or visible haematuria
•b. Known platelet count (<100,00/mm3 ) or coagulopathy or platelet disorder.
•c. History of major recent (<30 day) surgery or trauma
•4) Known Hb <6.5 mmol/L11g/dl or HCT <33%

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