Molecular Biology of Polycythemia and Thrombocytosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Identify the molecular defect of Polycythemic and Thrombocythemic disorders
研究概览
简要总结
Our study is designed to characterize the clinical picture and genetic pattern of Polycythemia and Thrombocytosis. The purpose of this project is to find a gene and its mutation that causes these disorders. When this is accomplished, new therapies to control and eventually cure the disorder can be designed.
详细描述
Our hypothesis is that genes and their mutation are causative of certain types of polycythemia and thrombocytosis. These will be sought for by genetic and cell biology means. The purpose of the study is to identify the molecular defect of these disorders.
5-7 teaspoons of peripheral blood will be drawn on all study subjects. After DNA is obtained, linkage analysis and/or mutation analysis will be performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with an elevated hemoglobin concentration (>18 in males and >16 in females)
- •Subjects with an elevated platelet count (>450,000)
排除标准
- •Subjects who have a known acquired cause of polycythemia and thrombocytosis
- •Subjects with heart disease, left to right heart shunt or severe pulmonary disease
研究组 & 干预措施
Affected Population
Subjects with an elevated hemoglobin concentration or an elevated platelet count
结局指标
主要结局
Identify the molecular defect of Polycythemic and Thrombocythemic disorders
时间窗: Weekly
次要结局
未报告次要终点