Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation

Completed

• Conditions: Ventilator Weaning

• Registration Number: NCT03433105
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant. Otherwise, if the work load was above the patient's AT, the oxygen uptake will increase.

1. Patient: who have tracheostomy tubes and with prolonged mechanical ventilation

2. Measurement: oxygen uptake(V̇O2) and respiratory mechanics during the spontaneous breathing trials

3. Outcome: Correlation between the oxygen uptake(V̇O2) and the weaning outcome

2.Specific aims:

1. to investigate the prognostic value of oxygen uptake in weaning patients from prolonged mechanical ventilation

2. Subgroup analysis may suggest which weaning protocol potentially benefit the most for each population group (cardiovascular disease, chronic pulmonary disease, neuromuscular disease, cerebrovascular disease)

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-23
• Study First Submitted: 2018-01-23
• Study First Submitted QC: 2018-02-07
• Study First Posted: 2018-02-14
• Status Verified: 2019-09
• Primary Completion: 2020-08-14
• Study Completion: 2020-08-14
• Last Update Submitted: 2020-10-06
• Last Update Posted: 2020-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 157

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of oxygen uptake (V̇O2)	up to 12 hours during the spontaneous breathing trial	oxygen uptake during the spontaneous breathing trial

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan