Improved HRV, Inflammation Markers and Endothelial Function After TAVI
Completed
- Conditions
- Severe Aortic StenosisTAVI
- Interventions
- Diagnostic Test: Flow mediated vasodilatationDiagnostic Test: High resolution ECGDiagnostic Test: Blood withdrawal
- Registration Number
- NCT04286893
- Lead Sponsor
- University Medical Centre Ljubljana
- Brief Summary
Severe aortic valve stenosis is known to affect heart haemodynamics, endothelial function and body inflammation markers. Our aim is to investigate the weather transcatheter aortic valve implantation in patients with severe aortic stenosis affects heart rate variability, inflammation markers and endothelial function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- TAVI
Exclusion Criteria
- stage V chronic kidney disease
- active malignancies
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description TAVI group Flow mediated vasodilatation Consecutive patients undergoing TAVI TAVI group Blood withdrawal Consecutive patients undergoing TAVI TAVI group High resolution ECG Consecutive patients undergoing TAVI
- Primary Outcome Measures
Name Time Method Change of flow-mediated filatation (FMD) of the brachial artery 3 to 6 months after TAVI % flow-mediated dilatation
Change of laboratory value of endothelial inflammation markers 3 to 6 months after TAVI Laboratory determined numerical changes in endothelial inflammation markers
Change of heart rate variability 3 to 6 months after TAVI Change of heart rate variability (HRV) estimated with digital high resolution ECG recording
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UMC Ljubljana
🇸🇮Ljubljana, Slovenia