Improved Heart Rate Variability, Inflammation Markers and Endothelial Function After Transcatheter Aortic Valve Implantation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Severe Aortic Stenosis
- Sponsor
- University Medical Centre Ljubljana
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Change of laboratory value of endothelial inflammation markers
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Severe aortic valve stenosis is known to affect heart haemodynamics, endothelial function and body inflammation markers. Our aim is to investigate the weather transcatheter aortic valve implantation in patients with severe aortic stenosis affects heart rate variability, inflammation markers and endothelial function.
Investigators
Luka Vitez
Luka Vitez, MD, cardiology resident
University Medical Centre Ljubljana
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •stage V chronic kidney disease
- •active malignancies
Outcomes
Primary Outcomes
Change of laboratory value of endothelial inflammation markers
Time Frame: 3 to 6 months after TAVI
Laboratory determined numerical changes in endothelial inflammation markers
Change of flow-mediated filatation (FMD) of the brachial artery
Time Frame: 3 to 6 months after TAVI
% flow-mediated dilatation
Change of heart rate variability
Time Frame: 3 to 6 months after TAVI
Change of heart rate variability (HRV) estimated with digital high resolution ECG recording