Study on CircRNA-Uck2 as a New Diagnostic Marker of Acute Myocardial Infarction
试验速览
- 阶段
- 不适用
- 入组人数
- 178
- 试验地点
- 1
- 主要终点
- The change of cUck2 levels in AMI
研究概览
简要总结
This is an observational diagnostic study that aims to evaluate the diagnostic value of circRNA-Uck2 in Acute Myocardial Infarction (AMI) in adults as compared to healthy and unstable angina controls. Rapid and adequate diagnosis of AMI is of great importance to enable a rapid start of treatment, save large tracts of dying myocardium, reduce the infarct size,and thereby decrease the risk of subsequent heart failure.
详细描述
RATIONAL acute myocardial infarction (AMI) is the leading cause of sudden death and heart failure worldwide. And about 10% of all emergency department consultations are with symptoms suggestive of AMI, however, only 10% to 20% of them are diagnosed as experiencing an AMI. Rapid and accurate identification of AMI is of paramount clinical importance for subsequent timely and effectively treatment and management.
Recently, the investigators identified microarray analysis and real-time polymerase chain reaction (PCR) from AMI animal models and small samples of AMI patients, a molecular signature of AMI involving 5 circRNAs (circRNA_006877, circRNA_015350, circRNA_002969, circRNA_013240, circRNA_004682) was found significantly change in AMI patients and likely serves as candidate serum biomarkers of AMI. Among the 5 circRNAs, circRNA_006877 name of circRNA-Uck2 (cUck2) has more close association with AMI.
TYPE OF STUDY : multicenter diagnostic evaluation Study MAIN PURPOSE OF THE STUDY : To evaluate the diagnostic value of circRNAs in AMI in adults as compared to healthy and unstable angina controls
SECONDARY OBJECTIVES :
assess the ability of cUck2 to discriminate a AMI disease from unstable angina patients in adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
盲法说明
Sample inspector
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Health Control Group:Pepole who have normal ECG, deny the history of cardiovascular disease can be included in the healthy control group.
- •Acute Myocardial Infarction Group:Clinical diagnosis of acute myocardial infarction
- •Unstable Angina Group:Clinical diagnosis of unstable angina.
- •Sign informed consent.
排除标准
- •Myocarditis, hypertrophic cardiomyopathy, ablation.
- •Malignant hypertension, severe arrhythmia.
- •Chronic muscle disorders, rhabdomyolysis.
- •Severe liver and kidney dysfunction.
- •Malignant tumors, acute cerebrovascular disease.
- •Severe neurosis, psychosis.
- •Patients who had any of the above were excluded.
结局指标
主要结局
The change of cUck2 levels in AMI
时间窗: It is totally 7 time points to detect cUck2, including the moment of admission, and the 1st day、the 2nd day、the 3th day、the 7th day、the 14th day、the 6th month after admission in AMI patients.
The investigators has found cUck2 has more close association with AMI.Detect cUck2 levels in different time points and it will give more information about its diagnostic value in AMI.
次要结局
未报告次要终点
研究者
Hong-Jin Wu
Clinical Professor
Beijing Haidian Hospital