Resistance Training on Growth Factors
- Conditions
- Cognitive Function
- Interventions
- Other: High intensity resistance trainingOther: Low intensity resistance training
- Registration Number
- NCT06114550
- Lead Sponsor
- Air Force Military Medical University, China
- Brief Summary
The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:
1. Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.
2. whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.
Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).
Researchers will compare the training effects of two different training on these growth factors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Male
- Target Recruitment
- 12
- age between 18 to 30 years
- no experiencing musculoskeletal disorders or sports injuries
- had not participated any regular aerobic endurance or resistance training with in the previous half years
- no smoking habit or intake alcohol and other medication (e.g., steroid hormone)
- good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)
- experiencing musculoskeletal disorders or sports injuries in recent 1 month
- had regular resistance training exercise
- intake any supplementary(drug and hormone)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description High-intensity resistance training group (HIRT) High intensity resistance training All subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set. low-intensity resistance training group (LIRT) Low intensity resistance training All subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order.
- Primary Outcome Measures
Name Time Method Blood lactate "0 minutes" "60 minutes" "90 minutes" serum blood lactate
BDNF "0 minutes" "60 minutes" "90 minutes" regulators of neurogenesis
IGF-1 "0 minutes" "60 minutes" "90 minutes" regulators of neurogenesis
Irisin "0 minutes" "60 minutes" "90 minutes" regulators of neurogenesis
Hcy "0 minutes" "60 minutes" "90 minutes" homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction
Rata of perceived exertion "0 minutes" "60 minutes" "90 minutes" The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.
VEGF "0 minutes" "60 minutes" "90 minutes" regulators of neurogenesis
- Secondary Outcome Measures
Name Time Method Accuracy rate "0 minutes" "60 minutes" "90 minutes" Accuracy refers to the correct degree of expression or description of a thing, which is used to reflect the correct answer to the thing
Reactive time "0 minutes" "60 minutes" "90 minutes" Reaction time is the time it takes for the body to go from receiving a stimulus to responding to an action