to analyse the markers of pain in the gum fluid after putting small holes in the gums
Phase 1
- Registration Number
- CTRI/2018/05/014121
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Cases of class II div I or bimaxillary protusion requiring bilateral 1st premolar extraction
Age 15 to 25
Erupted canines, premolars and 1st molars
No significant medical history or medication that would adversely affect the development of teeth or tooth movement
Positive informed consent
Exclusion Criteria
Non compliant patient with inability to maintain oral hygiene
history of any drug intake
Previous orthodontic treatment
Not wiling for informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Biochemical changes of IL-1beta during microsteoperforationTimepoint: o hour 1 hour 24 hour 1 week 21 days 28 days 72 days 120 days
- Secondary Outcome Measures
Name Time Method analysis of differential expression of IL-1Beta on single versus subsequent microosteoperforation in terms of inflammationTimepoint: o hour 1 hour 24 hour 1 week 21 days 28 days 72 days 120 days