The CZT Dynamic Myocardial Perfusion Imaging

Completed

• Conditions: Cardiac Disease

• Registration Number: NCT02697760
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

To develop and validate the noninvasive measurement of MBF and MFR by using dynamic imaging with a CZT camera, and evaluate the diagnostic and prognostic implications in various heart disease.

Detailed Description

Absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provide incremental diagnostic and prognostic information over relative perfusion alone. Recent development of dedicated cardiac SPECT cameras with better sensitivity and temporal resolution make dynamic SPECT imaging more practical. The potential roles of myocardial perfusion in subjects with cardiovascular risks and heart failure warrant further investigations.

The present project aims to develop and validate the noninvasive measurement of MBF and MFR by using dynamic imaging with a CZT camera, and evaluate the diagnostic and prognostic implications.

Study Timeline

• Study Start: 2015-09
• Study First Submitted: 2016-02-27
• Study First Submitted QC: 2016-02-27
• Study First Posted: 2016-03-03
• Primary Completion: 2018-12
• Status Verified: 2022-10
• Study Completion: 2022-10
• Last Update Submitted: 2022-10-20
• Last Update Posted: 2022-10-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 234

Inclusion Criteria

1. Coronary heart disease
2. Clinical diagnosis of heart failure
3. Clinical diagnosis of metabolic diseases (such as metabolic syndrome, obesity, diabetes, hyperlipidemia, micro vascular diseases, etc.), heart failure or coronary heart disease in high-risk groups persons.

Exclusion Criteria

Significant systemic disease (except heart disease) such as cirrhosis, end-stage renal disease or active malignancy, estimated life expectancy of less than three months, persons; pregnant or lactating women have the possibility of pregnancy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary artery disease (CAD) diagnosis	12 months after the index MPI	CAD defined as more than 50% stenosis in any vessel by coronary angiography or computed tomography.

Secondary Outcome Measures

Name	Time	Method
MACE (major adverse cardiac events)	5 years after the index MPI	revascularization, acute myocardial infarction, hospitalization for heart failure, cardiac death, non-cardiac death

Trial Locations

Locations (1)

Far Eastern Memorial Hospital; 🇨🇳 New Taipei City, Taiwan