CLA and Vitamin D on Protein Turnover

Not Applicable

Completed

• Conditions: Protein
• Interventions: Dietary Supplement: Conjugated linoleic acid and Vitamin D; Other: Corn oil (placebo); Dietary Supplement: Vitamin D; Dietary Supplement: Conjugated linoleic acid

• Registration Number: NCT03115775
• Lead Sponsor: Washington University School of Medicine

Brief Summary

To conduct a randomized, double-blind, controlled clinical trial to determine the independent and combined effects of dietary conjugated linoleic acid (CLA) and vitamin D supplementation on anabolic signaling, the expression of growth regulatory factors, and muscle protein turnover in older adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-04-07
• Study First Submitted QC: 2017-04-11
• Study First Posted: 2017-04-14
• Study Start: 2017-05-12
• Primary Completion: 2019-08-31
• Study Completion: 2019-08-31
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-20
• Last Update Posted: 2019-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• BMI >/= 18.5 and </= 35.0
• Serum 25OH-VitD3 < 35 ng/ml

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Exclusion Criteria

• Diabetes
• COPD

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Conjugated linoleic acid and Vitamin D	Conjugated linoleic acid and Vitamin D	Conjugated linoleic acid (4000 mg Tonalin FFA 80) and Vitamin D (2000 IU) per day
Placebo	Corn oil (placebo)	Corn oil (4000 mg per day)
Vitamin D	Vitamin D	Vitamin D3 (2000 IU per day)
Conjugated linoleic acid (Tonalin)	Conjugated linoleic acid	Conjugated linoleic acid (4000 mg Tonalin FFA 80 per day)

Primary Outcome Measures

Name	Time	Method
Change in post-absorptive muscle protein synthesis	Baseline and 8 weeks	A stable isotope labelled amino acid infusion, in conjunction with blood and muscle tissue sampling and mathematical modelling analysis will be used to measure post-absorptive muscle protein synthesis.
Change in combined amino acid and insulin stimulated muscle protein synthesis	Baseline and 8 weeks	A stable isotope labelled amino acid infusion, in conjunction with insulin and mixed amino acid infusion, blood and muscle tissue sampling and mathematical modelling analysis will be used to measure muscle protein synthesis.

Trial Locations

Locations (1)

Washington University; 🇺🇸 Saint Louis, Missouri, United States