CLA and Vitamin D on Protein Turnover

Not Applicable

Completed

• Conditions: Protein

• Registration Number: NCT03115775
• Lead Sponsor: Washington University School of Medicine

Brief Summary

To conduct a randomized, double-blind, controlled clinical trial to determine the independent and combined effects of dietary conjugated linoleic acid (CLA) and vitamin D supplementation on anabolic signaling, the expression of growth regulatory factors, and muscle protein turnover in older adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-04-07
• Study First Submitted QC: 2017-04-11
• Study First Posted: 2017-04-14
• Study Start: 2017-05-12
• Primary Completion: 2019-08-31
• Study Completion: 2019-08-31
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-20
• Last Update Posted: 2019-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• BMI >/= 18.5 and </= 35.0
• Serum 25OH-VitD3 < 35 ng/ml

Exclusion Criteria

• Diabetes
• COPD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in post-absorptive muscle protein synthesis	Baseline and 8 weeks	A stable isotope labelled amino acid infusion, in conjunction with blood and muscle tissue sampling and mathematical modelling analysis will be used to measure post-absorptive muscle protein synthesis.
Change in combined amino acid and insulin stimulated muscle protein synthesis	Baseline and 8 weeks	A stable isotope labelled amino acid infusion, in conjunction with insulin and mixed amino acid infusion, blood and muscle tissue sampling and mathematical modelling analysis will be used to measure muscle protein synthesis.

Trial Locations

Locations (1)

Washington University; 🇺🇸 Saint Louis, Missouri, United States