A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy
- Conditions
- Crohn's Disease
- Interventions
- Drug: Matching Placebo for Upadacitinib
- Registration Number
- NCT03345836
- Lead Sponsor
- AbbVie
- Brief Summary
The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and severely active Crohn's disease (CD).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 624
- Confirmed diagnosis of CD for at least 3 months prior to Baseline.
- Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score.
- Evidence of mucosal inflammation based on the Simplified Endoscopic Score for Crohn's disease (SES-CD) on an endoscopy confirmed by a central reader.
- Demonstrated an inadequate response or intolerance to any biologic therapy for infliximab, adalimumab, certolizumab pegol, vedolizumab, and ustekinumab.
- If female, participant must meet the contraception recommendations.
- Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
- Participant not on stable doses of CD related antibiotics, oral aminosalicylates, corticosteroids or methotrexate (MTX).
- Participant with the following ongoing known complications of CD: abscess (abdominal or peri-anal), symptomatic bowel strictures, fulminant colitis, toxic megacolon, or any other manifestation that might require surgery while enrolled in the study.
- Participant with ostomy or ileoanal pouch.
- Participant diagnosed with conditions that could interfere with drug absorption including but not limited to short gut or short bowel syndrome.
- Screening laboratory and other protocol pre-specified analyses show abnormal results.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Part 1 (Double-blind): Placebo Matching Placebo for Upadacitinib Participants received upadacitinib matching placebo tablets, orally, once daily (QD) for 12 weeks during the Double-blind (DB) Induction Period. Part 1 (Double-blind): Upadacitinib 45 mg Upadacitinib Participants received upadacitinib 45 mg tablets, orally, QD for 12 weeks during the DB Induction Period. Part 2 (Open-label): Upadacitinib 45 mg Upadacitinib Participants received upadacitinib 45 mg tablets, orally, QD for 12 weeks during the Open-label (OL) Induction Period. Part 3 (Extended Treatment DB): Upadacitinib 45 mg From Part 1 DB Placebo Upadacitinib Participants received upadacitinib 45 mg tablets, orally, QD for 12 weeks (until Week 24) during the Extended Treatment (ET) Period. Participants who received placebo in Part 1 and did not achieve clinical response at Week 12 were included in this group. Part 3 (Extended Treatment DB): Upadacitinib 30 mg From Part 1 DB Upadacitinib 45 mg Upadacitinib Participants received upadacitinib 30 mg tablets, orally, QD for 12 weeks (until Week 24) during the ET Period. Participants who received DB upadacitinib 45 mg in Part 1 and did not achieve clinical response at Week 12 were included in this group. Part 3 (Extended Treatment OL): Upadacitinib 30 mg From Part 2 OL Upadacitinib 45 mg Upadacitinib Participants received upadacitinib 30 mg tablets, orally, QD for 12 weeks (until Week 24) during the ET Period. Participants who received OL upadacitinib 45 mg during Part 2 and did not achieve clinical response at Week 12 were included in this group.
- Primary Outcome Measures
Name Time Method Percentage of Participants With Clinical Remission Per Crohn's Disease Activity Index (CDAI) at Week 12 Week 12 The CDAI was used to evaluate the activity of Crohn's disease. Clinical remission per CDAI is defined as CDAI \<150. The CDAI is calculated on the basis of a one-week evaluation of 8 items: frequency of liquid or very soft stool, abdominal pain, complications of Crohn's disease (e.g., uveitis, arthritis, fistula, and abscess), abdominal mass, hematocrit, body weight, use of antidiarrheals, and general condition. Total score ranges from 0 to about 600. Higher CDAI scores indicate more severe disease. CDAI scores below 150 represent remission and scores over 450 represent very severe Crohn's disease. Results were based on non-responder imputation incorporating multiple imputation to handle missing data due to COVID-19 (NRI-C).
Number of Participants With Adverse Events From first dose of study drug until 30 days following last dose of study drug (up to approximately 28 weeks) An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not the event is considered causally related to the use of the product.
Percentage of Participants With Endoscopic Response at Week 12 Baseline to Week 12 Endoscopic response was defined as greater than 50% decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) from Baseline of the induction study (or for participants with an SES-CD of 4 at Baseline of the induction study, at least a 2-point reduction from Baseline), as scored by Central Reviewer. SES-CD is calculated based on the sum of individual segment values for four endoscopic variables (presence and size of ulcers, ulcerated surface, affected surface and presence of narrowing). Each variable in each segment is scored 0 to 3 resulting in SES-CD values ranging from 0 to 56 with higher scores indicating more severe disease. Results were based on NRI-C.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With Clinical Remission Per Patient-Reported Outcomes (PROs) at Week 12 Baseline to Week 12 Clinical remission per PROs was defined as average daily very soft or liquid stool frequency (SF) ≤2.8 and average daily abdominal pain (AP) score ≤1.0 and both not greater than Baseline. The number of soft or liquid stools and abdominal pain rated on a scale of 0=none to 3=severe were recorded in an electronic diary. Results were based on NRI-C.
Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Total Score at Week 12 Baseline and Week 12 The FACIT-F questionnaire was developed to assess fatigue associated with anemia. It consists of 13 fatigue-related questions. The responses to the 13 items on the FACIT-F questionnaire are each measured on a 5-point Likert scale. The responses to the answers are the following: 0= not at all; 1= a little bit; 2= somewhat; 3= quite a bit; 4=very much. Thus, the total score ranges from 0 to 52. High scores represent less fatigue. A positive change from Baseline indicates improvement.
Percentage of Participants With Clinical Remission Per Crohn's Disease Activity Index (CDAI) at Week 4 Week 4 The CDAI was used to evaluate the activity of Crohn's disease. Clinical remission per CDAI is defined as CDAI \<150. The CDAI is calculated on the basis of a one-week evaluation of 8 items: frequency of liquid or very soft stool, abdominal pain, complications of Crohn's disease (e.g., uveitis, arthritis, fistula, and abscess), abdominal mass, hematocrit, body weight, use of antidiarrheals, and general condition. Total score ranges from 0 to 600. Higher CDAI scores indicate more severe disease. CDAI scores below 150 represent remission and scores over 450 represent very severe Crohn's disease. Results were based on NRI-C.
Percentage of Participants Who Discontinued Corticosteroid Use for Crohn's Disease (CD) and Achieved Clinical Remission Per CDAI at Week 12, in Participants Taking Corticosteroids at Baseline Week 12 As prespecified in the protocol, this outcome measure was planned to be assessed in participants taking corticosteroids at Baseline. Clinical remission per CDAI: CDAI \<150. The CDAI is used to evaluate the activity of Crohn's disease. The CDAI is calculated on the basis of a one-week evaluation of 8 items: frequency of liquid or very soft stool, abdominal pain, complications of Crohn's disease (e.g., uveitis, arthritis, fistula, and abscess), abdominal mass, hematocrit, body weight, use of antidiarrheals, and general condition. Total score ranges from 0 to about 600. Higher CDAI scores indicate more severe disease. CDAI scores below 150 represent remission and scores over 450 represent very severe Crohn's disease. Results were based on NRI-C.
Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 12 Baseline and Week 12 The IBDQ is a disease-specific instrument composed of 32 Likert-scaled items. The IBDQ scale contains 4 component subscales: bowel symptoms (10 items), systemic symptoms (5 items), emotional function (12 items), and social function(5 items). Each item is scored on a 7-point scale where: 1=worst to 7= best. The total score ranges from 32 to 224, with higher scores indicating better health-related quality of life. A positive change from Baseline indicates improvement.
Percentage of Participants Achieving Clinical Response 100 (CR-100) at Week 2 Baseline to Week 2 CR-100 is defined as a decrease of at least 100 points in CDAI from Baseline at Week 2. The CDAI is used to evaluate the activity of Crohn's disease. The CDAI is calculated on the basis of a one-week evaluation of 8 items: frequency of liquid or very soft stool, abdominal pain, complications of Crohn's disease (e.g., uveitis, arthritis, fistula, and abscess), abdominal mass, hematocrit, body weight, use of antidiarrheals, and general condition. Total score ranges from 0 to about 600. Higher CDAI scores indicate more severe disease. CDAI scores below 150 represent remission and scores over 450 represent very severe Crohn's disease. Results were based on NRI-C.
Percentage of Participants With Endoscopic Remission at Week 12 Baseline to Week 12 Endoscopic remission was defined per SES-CD. SES-CD ≤4 and at least 2-point reduction from Baseline and no subscore \>1 in any individual variable, as scored by Central Reviewer. SES-CD is calculated based on the sum of individual segment values for four endoscopic variables (presence and size of ulcers, ulcerated surface, affected surface and presence of narrowing). Each variable in each segment is scored 0 to 3 resulting in SES-CD values ranging from 0 to 56 with higher scores indicating more severe disease. Results were based on NRI-C.
Percentage of Participants Achieving Clinical Response 100 (CR-100) at Week 12 Baseline to Week 12 CR-100 is defined as a decrease of at least 100 points in CDAI from Baseline at Week 12. The CDAI is used to evaluate the activity of Crohn's disease. The CDAI is calculated on the basis of a one-week evaluation of 8 items: frequency of liquid or very soft stool, abdominal pain, complications of Crohn's disease (e.g., uveitis, arthritis, fistula, and abscess), abdominal mass, hematocrit, body weight, use of antidiarrheals, and general condition. Total score ranges from 0 to about 600. Higher CDAI scores indicate more severe disease. CDAI scores below 150 represent remission and scores over 450 represent very severe Crohn's disease. Results were based on NRI-C.
Percentage of Participants With Hospitalizations Due to Crohn's Disease (CD) During Part 1 (12-week Double-blind Induction Period) Up to Week 12 in Part 1: Double-blind Induction Period Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs) at Week 12, in Participants With EIMs at Baseline Week 12 EIMs are defined as manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver. Results were based on NRI-C.
Trial Locations
- Locations (428)
Cardio Alem /ID# 211284
🇦🇷San Isidro, Buenos Aires, Argentina
Facey Medical Foundation /ID# 203137
🇺🇸Mission Hills, California, United States
CB Flock Research Corporation /ID# 166220
🇺🇸Mobile, Alabama, United States
University of Chicago Medicine /ID# 165472
🇺🇸Chicago, Illinois, United States
Atlanta Gastroenterology Spec /ID# 164780
🇺🇸Suwanee, Georgia, United States
Aquiant Research /ID# 205504
🇺🇸New Albany, Indiana, United States
CHU Toulouse - Hopital Rangueil /ID# 169785
🇫🇷Toulouse, France
Arizona Arthritis & Rheumatology Research, PLLC /ID# 203891
🇺🇸Sun City, Arizona, United States
United Medical Doctors - Murrieta /ID# 164845
🇺🇸Murrieta, California, United States
Duplicate_Western States Clinical Research, Inc. /ID# 164895
🇺🇸Wheat Ridge, Colorado, United States
Peak Gastroenterology Associates, PC /ID# 170181
🇺🇸Colorado Springs, Colorado, United States
Citrus Valley Gastroenterology /ID# 166201
🇺🇸Covina, California, United States
Gastro Center of Maryland /ID# 171171
🇺🇸Columbia, Maryland, United States
DuPage Medical Group /ID# 205303
🇺🇸Downers Grove, Illinois, United States
Clinical Research of West Florida, Inc /ID# 205825
🇺🇸Clearwater, Florida, United States
Care Access Research /ID# 167766
🇺🇸San Pablo, California, United States
Inquest Clinical Research /ID# 164865
🇺🇸Baytown, Texas, United States
Columbia Univ Medical Center /ID# 164870
🇺🇸New York, New York, United States
MediSphere Medical Research Center /ID# 166209
🇺🇸Evansville, Indiana, United States
CroNOLA, LLC /ID# 164722
🇺🇸Houma, Louisiana, United States
University of Iowa Hospitals and Clinics /ID# 165330
🇺🇸Iowa City, Iowa, United States
Nola Research Works, LLC /ID# 164897
🇺🇸New Orleans, Louisiana, United States
Center for Digestive Health /ID# 164733
🇺🇸Troy, Michigan, United States
NYU Langone Long Island Clinical Research Associates /ID# 164830
🇺🇸Lake Success, New York, United States
Encore Borland-Groover Clinical Research /Id# 203498
🇺🇸Jacksonville, Florida, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 165460
🇺🇸Macon, Georgia, United States
Advantage Clinical Trials /ID# 168557
🇺🇸Bronx, New York, United States
Medical Research Center of CT /ID# 164829
🇺🇸Hamden, Connecticut, United States
MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 164835
🇺🇸Chevy Chase, Maryland, United States
Louisana Research Center, LLC /ID# 164659
🇺🇸Shreveport, Louisiana, United States
Clinical Research of West Florida, Inc /ID# 208117
🇺🇸Clearwater, Florida, United States
Johns Hopkins University School of Medicine /ID# 211940
🇺🇸Baltimore, Maryland, United States
Gastro Group of Rochester /ID# 166216
🇺🇸Rochester, New York, United States
Clin Res Inst of Michigan, LLC /ID# 170178
🇺🇸Chesterfield, Michigan, United States
NY Scientific /ID# 164833
🇺🇸Brooklyn, New York, United States
Great Lakes Medical Research, LLC /ID# 202007
🇺🇸Mentor, Ohio, United States
Cleveland Clinic Main Campus /ID# 208220
🇺🇸Cleveland, Ohio, United States
The Ohio State University /ID# 170174
🇺🇸Columbus, Ohio, United States
Atrium Health Carolinas Medical Center /ID# 164834
🇺🇸Charlotte, North Carolina, United States
Mater Misericordiae Limited /ID# 204908
🇦🇺South Brisbane, Queensland, Australia
Optimed Research, Ltd. /ID# 205618
🇺🇸Columbus, Ohio, United States
TX Clinical Research Institute /ID# 164848
🇺🇸Arlington, Texas, United States
Gastro One /ID# 164718
🇺🇸Germantown, Tennessee, United States
East Tennessee Research Institute /ID# 203612
🇺🇸Johnson City, Tennessee, United States
Washington Gastroenterology Associates /ID# 164721
🇺🇸Bellevue, Washington, United States
Healthcare Research Consultant /ID# 166228
🇺🇸Tulsa, Oklahoma, United States
Gastroenterology Associates, P.A. of Greenville /ID# 164880
🇺🇸Greenville, South Carolina, United States
Royal Adelaide Hospital /ID# 171511
🇦🇺Adelaide, South Australia, Australia
HP Clinical Research /ID# 164929
🇺🇸Bountiful, Utah, United States
Concord Repatriation General Hospital /ID# 171509
🇦🇺Concord, New South Wales, Australia
Taunton Surgical Centre /ID# 168039
🇨🇦Oshawa, Ontario, Canada
Coral Sea Clinical Research institute /ID# 212987
🇦🇺North Mackay, Queensland, Australia
University Clinical Centre of the Republic of Srpska /ID# 208050
🇧🇦Banja Luka, Republika Srpska, Bosnia and Herzegovina
M y F Estudios Clínicos /ID# 169995
🇨🇱Santiago, Region Metropolitana Santiago, Chile
Upeclin Fmb - Unesp /Id# 166876
🇧🇷Botucatu, Sao Paulo, Brazil
Beijing Friendship Hospital /ID# 204536
🇨🇳Beijing, China
Hospital Provincial del Centenario /ID# 171254
🇦🇷Rosario, Santa Fe, Argentina
Box Hill Hospital /ID# 203734
🇦🇺Box Hill, Victoria, Australia
Hospital Nossa Senhora das Graças /ID# 166869
🇧🇷Curitiba, Parana, Brazil
Medizinische Universitaet Wien /ID# 169462
🇦🇹Vienna, Wien, Austria
The Ottawa Hospital /ID# 212413
🇨🇦Ottawa, Ontario, Canada
QEII - Health Sciences Centre /ID# 169306
🇨🇦Halifax, Nova Scotia, Canada
Hospital Guillermo Grant Benavente de Concepción /ID# 212422
🇨🇱Concepción, Chile
Allen Whey Khye Lim Professional Corporation /ID# 168041
🇨🇦Edmonton, Alberta, Canada
Toronto Digestive Disease Asso /ID# 166961
🇨🇦Vaughan, Ontario, Canada
The First Hospital of Jilin University /ID# 206867
🇨🇳Changchun, Jilin, China
MHAT Trakia /ID# 201678
🇧🇬Stara Zagora, Bulgaria
Crchum /Id# 170121
🇨🇦Montreal, Quebec, Canada
CTR Estudios Clinicos /ID# 200650
🇨🇱Providencia, Chile
Faculdade de Medicina do ABC /ID# 208327
🇧🇷Santo André, Sao Paulo, Brazil
Hospital Clinico Universidad De Los Andes /ID# 207465
🇨🇱Santiago, Chile
Hospital Pablo Tobon Uribe /ID# 202405
🇨🇴Medellín, Antioquia, Colombia
Hepato-Gastroenterologie HK, s.r.o. /ID# 171566
🇨🇿Hradec Kralove, Czechia
GIRI Gastrointestinal Research Institute /ID# 166964
🇨🇦Vancouver, British Columbia, Canada
Fraser Clinical Trials Inc /ID# 166957
🇨🇦New Westminster, British Columbia, Canada
Covenant Health /ID# 166966
🇨🇦Edmonton, Alberta, Canada
Montreal General Hospital - McGill University Health Center /ID# 170010
🇨🇦Montreal, Quebec, Canada
Poliklinika Solmed /ID# 211518
🇭🇷Zagreb, Grad Zagreb, Croatia
Zadar General Hospital /ID# 205534
🇭🇷Zadar, Croatia
ResTrial s.r.o. /ID# 208652
🇨🇿Praha, Czechia
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 204078
🇨🇳Hangzhou, Zhejiang, China
Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 169067
🇩🇪Berlin, Germany
Gastroenterologie am Mexikoplatz /ID# 203573
🇩🇪Berlin, Germany
Medizinisches Versorgungszentrum Portal 10 /ID# 200213
🇩🇪Muenster, Germany
Duplicate_Hopital Saint Eloi /ID# 170646
🇫🇷Montpellier CEDEX 5, Herault, France
Clinical Research Center, Faculty of Medicine, Cairo university /ID# 209557
🇪🇬Cairo, Egypt
National Hepatology and Tropical Medicine Research Institute /ID# 170990
🇪🇬Cairo, Egypt
A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 168173
🇮🇹Bologna, Italy
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171010
🇪🇬Alexandria, Egypt
Magyar Honvedseg Egeszsegugyi Kozpont /ID# 201719
🇭🇺Budapest, Hungary
Duplicate_CHU Henri Mondor /ID# 169787
🇫🇷Creteil, France
Universitaetsklinikum Halle (Saale) /ID# 207454
🇩🇪Halle (Saale), Germany
Universitaetsklinikum Frankfurt /ID# 203565
🇩🇪Frankfurt am Main, Hessen, Germany
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171015
🇪🇬Alexandria, Egypt
Agaplesion Markus Krankenhaus /ID# 168777
🇩🇪Frankfurt am Main, Germany
HCL - Hôpital Lyon Sud /ID# 171014
🇫🇷Pierre Benite CEDEX, Auvergne-Rhone-Alpes, France
Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203571
🇩🇪Essen, Germany
Universitaetsklinikum Ulm /ID# 203563
🇩🇪Ulm, Baden-Wuerttemberg, Germany
General Hospital of Athens Ippokratio /ID# 167036
🇬🇷Athens, Attiki, Greece
Digestive Disease Center Gastro /ID# 169517
🇱🇻Riga, Latvia
Dong-A University Hospital /ID# 167582
🇰🇷Busan, Korea, Republic of
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 167037
🇬🇷Athens, Greece
Istituto Clinico Humanitas /ID# 168171
🇮🇹Rozzano, Milano, Italy
A.O. Per L'Emergenza Cannizzaro /ID# 168176
🇮🇹Catania, Italy
Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202420
🇮🇹Pisa, Italy
Mentahaz Maganorvosi Kozpont /ID# 201890
🇭🇺Szekesfehervar, Hungary
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 168175
🇮🇹Palermo, Italy
Kanazawa University Hospital /ID# 169215
🇯🇵Kanazawa-shi, Ishikawa, Japan
CHA University Bundang Medical Center /ID# 167583
🇰🇷Seongnam si, Gyeonggido, Korea, Republic of
Japanese Red Cross Kyoto Daiichi Hosital /ID# 165958
🇯🇵Kyoto-shi, Kyoto, Japan
Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 166002
🇯🇵Kurashiki-shi, Okayama, Japan
Idzuro Imamura Hospital /ID# 206651
🇯🇵Kagoshima-shi, Kagoshima, Japan
Chung-Ang University Hostipal /ID# 207017
🇰🇷Seoul, Korea, Republic of
Kyoto University Hospital /ID# 169888
🇯🇵Kyoto-shi, Kyoto, Japan
Okayama University Hospital /ID# 167355
🇯🇵Okayama-shi, Okayama, Japan
Pusan National University Hospital /ID# 167580
🇰🇷Busan, Korea, Republic of
Pauls Stradins Clinical University Hospital /ID# 169493
🇱🇻Riga, Latvia
Hayang University GuriHospital /ID# 167578
🇰🇷Guri, Gyeonggido, Korea, Republic of
Kyungpook National Univ Hosp /ID# 207015
🇰🇷Daegu, Korea, Republic of
Mersin University Medical /ID# 171320
🇹🇷Mersin, Turkey
Vistamed /ID# 208570
🇵🇱Wroclaw, Dolnoslaskie, Poland
Mindful Medical Research /ID# 203357
🇵🇷San Juan, Puerto Rico
Immanuel Kant Baltic Federal University /ID# 202128
🇷🇺Kaliningrad, Kaliningradskaya Oblast, Russian Federation
Clinical Hosp Center Zvezdara /ID# 168221
🇷🇸Belgrade, Beograd, Serbia
City Clinical Hospital No. 31 /ID# 208870
🇷🇺St. Petersburg, Russian Federation
Euromedservice /ID# 206609
🇷🇺Pushkin, Russian Federation
Hospital Universitario A Coruna - CHUAC /ID# 203908
🇪🇸A Coruna, Spain
Lenasia Clinical Trial Centre /ID# 205144
🇿🇦Johannesburg, Gauteng, South Africa
Hospital Universitario Vall d'Hebron /ID# 171237
🇪🇸Barcelona, Spain
Warrington and Halton Hospitals NHS Foundation Trust /ID# 171388
🇬🇧Warrington, Cheshire West And Chester, United Kingdom
Coral Research Clinic /ID# 164657
🇺🇸Miami, Florida, United States
Crystal Pharmacology Research /ID# 166101
🇺🇸Miami, Florida, United States
Indianapolis Gastroenterology /ID# 164837
🇺🇸Indianapolis, Indiana, United States
Baylor College of Medicine - Baylor Medical Center /ID# 164847
🇺🇸Houston, Texas, United States
Centex Studies, Inc. - Houston /ID# 201213
🇺🇸Houston, Texas, United States
GI Specialists of Houston /ID# 202338
🇺🇸Houston, Texas, United States
Virginia Mason - Seattle Orthapedics /ID# 164680
🇺🇸Seattle, Washington, United States
University of Washington /ID# 164875
🇺🇸Seattle, Washington, United States
Ucsd /Id# 164679
🇺🇸San Diego, California, United States
Medical Assoc Research Grp /ID# 169705
🇺🇸San Diego, California, United States
Las Vegas Medical Research /ID# 168562
🇺🇸Las Vegas, Nevada, United States
University of Cincinnati /ID# 164720
🇺🇸Cincinnati, Ohio, United States
Azienda Ospedaliera San Camillo Forlanini /ID# 168170
🇮🇹Rome, Lazio, Italy
Genl Hosp Thess Ippokrateio /ID# 208824
🇬🇷Thessaloniki, Greece
Bugat Pal Korhaz /ID# 201889
🇭🇺Gyöngyös, Heves, Hungary
Barzilai Medical Center /ID# 223372
🇮🇱Ashkelon, Israel
Hirosaki National Hospital /ID# 165944
🇯🇵Hirosaki-shi, Aomori, Japan
Kurume University Hospital /ID# 166004
🇯🇵Kurume-shi, Fukuoka, Japan
National Hospital Organization Takasaki General Medical Center /ID# 167136
🇯🇵Takasaki-shi, Gunma, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165943
🇯🇵Sapporo-shi, Hokkaido, Japan
Hiroshima University Hospital /ID# 166006
🇯🇵Hiroshima-shi, Hiroshima, Japan
Iwate Medical University Uchimaru Medical Center /ID# 202407
🇯🇵Morioka-shi, Iwate, Japan
Tohoku University Hospital /ID# 167135
🇯🇵Sendai-shi, Miyagi, Japan
Nara Medical University Hospital /ID# 169216
🇯🇵Kashihara-shi, Nara, Japan
Kenseikai Dongo Hospital /ID# 208103
🇯🇵Yamatotakada-shi, Nara, Japan
Osaka City University Hospital /ID# 166007
🇯🇵Osaka-shi, Osaka, Japan
NHO Shizuoka Medical Center /ID# 167138
🇯🇵Sunto-gun, Shizuoka, Japan
The Jikei University Hospital /ID# 167142
🇯🇵Minato-ku, Tokyo, Japan
Shiga University of Medical Science Hospital /ID# 167141
🇯🇵Otsu-shi, Shiga, Japan
Medisch Spectrum Twente /ID# 170297
🇳🇱Enschede, Netherlands
Hospital Egas Moniz /ID# 170249
🇵🇹Lisbon, Porto, Portugal
Institutul Clinic Fundeni /ID# 167826
🇷🇴Sector 2, Bucuresti, Romania
Clinica GASTRO MED SRL /ID# 206367
🇷🇴Cluj-Napoca, Cluj, Romania
Military Medical Academy /ID# 168784
🇷🇸Belgrade, Beograd, Serbia
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204096
🇨🇳Wuhan, Hubei, China
Nanjing Drum Tower Hospital /ID# 204869
🇨🇳Nanjing, Jiangsu, China
Zhongshan Hospital Xiamen University /ID# 204985
🇨🇳Fujian, Anhui, China
The First Affiliated Hospital of Nanchang University /ID# 204070
🇨🇳Nanchang, Jiangxi, China
The Second Hospital Central South University /ID# 204075
🇨🇳Changsha, China
Nanfang Hospital of Southern Medical University /ID# 204074
🇨🇳Guangzhou, China
Duplicate_Tianjin Med Univ General Hosp /ID# 206993
🇨🇳Tianjin, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 204069
🇨🇳Wuhan, China
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168779
🇩🇪Kiel, Schleswig-Holstein, Germany
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168172
🇮🇹Negrar, Verona, Italy
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206740
🇩🇪Saarbrücken, Saarland, Germany
Hospital de Clinicas de Porto Alegre /ID# 166872
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Velocity Clinical Research - Salt Lake City /ID# 166095
🇺🇸West Jordan, Utah, United States
East View Medical Research, LLC /ID# 171133
🇺🇸Mobile, Alabama, United States
Southern California Res. Ctr. /ID# 169654
🇺🇸Coronado, California, United States
United Medical Doctors /ID# 207452
🇺🇸Los Alamitos, California, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164887
🇺🇸Los Angeles, California, United States
Nordsjaellands Hospital /ID# 200613
🇩🇰Frederikssund, Hovedstaden, Denmark
Herlev Hospital /ID# 200782
🇩🇰Herlev, Hovedstaden, Denmark
Delta Waves, Inc. /ID# 164872
🇺🇸Colorado Springs, Colorado, United States
Ctr for Advanced Gastroenterol /ID# 165332
🇺🇸Maitland, Florida, United States
Advanced Research Institute, Inc /ID# 164814
🇺🇸New Port Richey, Florida, United States
Advanced Research - Coral Springs /ID# 218020
🇺🇸Coral Springs, Florida, United States
Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 200611
🇩🇰Hvidovre, Hovedstaden, Denmark
Duplicate_Sjaellands Universitets Hospital /ID# 200783
🇩🇰Roskilde, Sjælland, Denmark
Gastroenterology Consultants PC - Roswell /ID# 218219
🇺🇸Roswell, Georgia, United States
Tri-State Gastroenterology /ID# 165484
🇺🇸Crestview Hills, Kentucky, United States
Digestive Health Associates (DHA) - Farmington Hills /ID# 206099
🇺🇸Farmington Hills, Michigan, United States
Montefiore Medical Center - Moses Campus /ID# 166226
🇺🇸Bronx, New York, United States
Rutgers Robert Wood Johnson /ID# 166092
🇺🇸New Brunswick, New Jersey, United States
PMG Research of Charlotte /ID# 171170
🇺🇸Charlotte, North Carolina, United States
Richmond University Medical Center /ID# 201855
🇺🇸Staten Island, New York, United States
Plains Clinical Research Center, LLC /ID# 170184
🇺🇸Fargo, North Dakota, United States
Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164663
🇺🇸Raleigh, North Carolina, United States
Consultants for Clinical Research /ID# 164855
🇺🇸Cincinnati, Ohio, United States
Hometown Urgent Care and Resea /ID# 201290
🇺🇸Dayton, Ohio, United States
University of Pennsylvania /ID# 168402
🇺🇸Philadelphia, Pennsylvania, United States
Options Health Research, LLC /ID# 164737
🇺🇸Tulsa, Oklahoma, United States
Dayton Gastroenterology, Inc. /ID# 167624
🇺🇸Englewood, Ohio, United States
Thomas Jefferson University /ID# 168014
🇺🇸Philadelphia, Pennsylvania, United States
Rapid City Medical Center - GI Research /ID# 201734
🇺🇸Rapid City, South Dakota, United States
Texas Digestive Disease Consultants /ID# 209802
🇺🇸Cedar Park, Texas, United States
Allegiance Research Specialists /ID# 165321
🇺🇸Wauwatosa, Wisconsin, United States
Gedyt /ID# 210019
🇦🇷Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Fiona Stanley Hospital /ID# 171510
🇦🇺Murdoch, Western Australia, Australia
Klinik Landstrasse /ID# 203437
🇦🇹Vienna, Wien, Austria
CHU de Liege Sart Tilman /ID# 200299
🇧🇪Liège, Liege, Belgium
Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 214467
🇦🇹Salzburg, Austria
CHU UCL Namur - site Godinne /ID# 200300
🇧🇪Godinne, Namur, Belgium
Universitair Ziekenhuis Leuven /ID# 200298
🇧🇪Leuven, Vlaams-Brabant, Belgium
AZ Sint-Lucas /ID# 200301
🇧🇪Gent, Belgium
University Clinical Center Tuzla /ID# 210324
🇧🇦Tuzla, Tuzlanski, Bosnia and Herzegovina
Clinical Center University of Sarajevo /ID# 203885
🇧🇦Sarajevo, Bosnia and Herzegovina
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166870
🇧🇷Goiânia, Goias, Brazil
Duplicate_Second MHAT Sofia /ID# 167618
🇧🇬Sofia, Bulgaria
Scott Shulman Medicine Professional Corporation /ID# 169064
🇨🇦North Bay, Ontario, Canada
CHAU- Hotel-Dieu de Levis /ID# 166958
🇨🇦Levis, Quebec, Canada
CIUSSS de l'Estrie - CHUS /ID# 170935
🇨🇦Sherbrooke, Quebec, Canada
Research Group /ID# 203180
🇨🇱Santiago, Region Metropolitana De Santiago, Chile
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204072
🇨🇳Shanghai, Shanghai, China
Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204068
🇨🇳Hangzhou, Zhejiang, China
Klinicki bolnicki centar Sestre milosrdnice /ID# 171190
🇭🇷Zagreb, Grad Zagreb, Croatia
ARTROSCAN s.r.o. /ID# 171592
🇨🇿Třebovice, Czechia
CHRU Lille - Hopital Claude Huriez /ID# 206539
🇫🇷Lille, Hauts-de-France, France
CHRU Nancy - Hôpitaux de Brabois /ID# 170985
🇫🇷Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France
Hopital Beaujon /ID# 171011
🇫🇷Clichy, Ile-de-France, France
Universitatsklinikum Mannheim /ID# 168778
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Universitaetsklinikum Erlangen /ID# 203551
🇩🇪Erlangen, Bayern, Germany
University General Hospital of Heraklion PA.G.N.I /ID# 167035
🇬🇷Heraklion, Kriti, Greece
Tel Aviv Sourasky Medical Center /ID# 204876
🇮🇱Tel Aviv-Yafo, Tel-Aviv, Israel
Hadassah Medical Center-Hebrew University /ID# 169927
🇮🇱Jerusalem, Israel
Policlinico Universitario Campus Bio-Medico /ID# 168169
🇮🇹Rome, Lazio, Italy
Fondazione PTV Policlinico Tor Vergata /ID# 168174
🇮🇹Rome, Roma, Italy
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 168168
🇮🇹Rome, Roma, Italy
ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168167
🇮🇹Milano, Italy
Aichi Medical University Hospital /ID# 165957
🇯🇵Nagakute-shi, Aichi, Japan
Toyohashi Municipal Hospital /ID# 200174
🇯🇵Toyohashi-shi, Aichi, Japan
Sapporo Medical University Hospital /ID# 167137
🇯🇵Sapporo-shi, Hokkaido, Japan
Imamura General Hospital /ID# 227136
🇯🇵Kagoshima-shi, Kagoshima, Japan
Kinshukai Infusion Clinic /ID# 218871
🇯🇵Osaka-shi, Osaka, Japan
Tokitokai Tokito clinic /ID# 165945
🇯🇵Saitama-shi, Saitama, Japan
Osaka University Hospital /ID# 169662
🇯🇵Suita-shi, Osaka, Japan
Yonsei University Health System Severance Hospital /ID# 167581
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Wakayama Medical University Hospital /ID# 169481
🇯🇵Wakayama-shi, Wakayama, Japan
Inje University Haeundae Hospital /ID# 202629
🇰🇷Busan, Korea, Republic of
Samsung Medical Center /ID# 167579
🇰🇷Seoul, Korea, Republic of
Riga East Clinical University Hospital /ID# 169496
🇱🇻Riga, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 207263
🇱🇹Kaunas, Lithuania
Morales Vargas Centro de Investigacion S.C. /ID# 203495
🇲🇽Leon, Guanajuato, Mexico
Academisch Medisch Centrum /ID# 166924
🇳🇱Amsterdam, Netherlands
WIP Warsaw IBD Point Profesor Kierkus /ID# 224300
🇵🇱Warsaw, Mazowieckie, Poland
Centrum Medyczne Reuma Park w Warszawie /ID# 200488
🇵🇱Warsaw, Mazowieckie, Poland
Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200606
🇵🇹Ponte de Lima, Viana Do Castelo, Portugal
Hospital Garcia de Orta, EPE /ID# 170234
🇵🇹Almada, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 170231
🇵🇹Porto, Portugal
School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166770
🇵🇷San Juan, Puerto Rico
Cabinet Particular Policlinic Algomed /ID# 167827
🇷🇴Timișoara, Romania
LLC Medical Center /ID# 209233
🇷🇺Novosibirsk, Novosibirskaya Oblast, Russian Federation
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202995
🇷🇺Stavropol, Stavropol Skiy Kray, Russian Federation
LLC Novaya Klinika /ID# 206615
🇷🇺Pyatigorsk, Stavropol Skiy Kray, Russian Federation
Republican hospital named after V.A. Baranov /ID# 206487
🇷🇺Petrozavodsk, Russian Federation
Olla-Med Clinic /ID# 208721
🇷🇺Moscow, Russian Federation
P.A. Bayandin Murmansk Regiona /ID# 169575
🇷🇺Murmansk, Russian Federation
UCSF Center for Colitis and Crohn's Disease /ID# 202373
🇺🇸San Francisco, California, United States
Univ of California San Francis /ID# 164843
🇺🇸San Francisco, California, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 164863
🇺🇸San Antonio, Texas, United States
Duplicate_Care Access Research /ID# 164853
🇺🇸Salt Lake City, Utah, United States
Digestive Disease Specialists /ID# 201062
🇺🇸Oklahoma City, Oklahoma, United States
Quality Medical Research /ID# 205262
🇺🇸Nashville, Tennessee, United States
Vanderbilt University Medical Center /ID# 164846
🇺🇸Nashville, Tennessee, United States
Southern Star Research Institute, LLC /ID# 169754
🇺🇸San Antonio, Texas, United States
Clin Hosp Ctr Bezanijska Kosa /ID# 168799
🇷🇸Belgrade, Beograd, Serbia
KL Ling Gastroenterology and Liver Clinic /ID# 217963
🇸🇬Singapore, Singapore
Gleneagles Medical Centre /ID# 206530
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital /ID# 203159
🇸🇬Singapore, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169952
🇸🇰Banska Bystrica, Slovakia
KM Management, spol. s.r.o. /ID# 170199
🇸🇰Nitra, Slovakia
Wits Clinical Research Site /ID# 170851
🇿🇦Johannesburg, Gauteng, South Africa
Dr JP Wright /ID# 170885
🇿🇦Cape Town, Western Cape, South Africa
Hospital Unversitario Marques de Valdecilla /ID# 202039
🇪🇸Santander, Cantabria, Spain
Private Practice Dr MN Rajabally /ID# 169852
🇿🇦Cape Town, Western Cape, South Africa
Hospital Universitari Son Espases /ID# 201997
🇪🇸Palma de Mallorca, Illes Balears, Spain
Complejo Hospitalario de Navarra /ID# 202038
🇪🇸Pamplona, Navarra, Spain
Hospital Universitario Dr. Negrin /ID# 171238
🇪🇸Las Palmas de Gran Canaria, Las Palmas, Spain
Hospital Clinic de Barcelona /ID# 171242
🇪🇸Barcelona, Spain
Hospital Universitario de Girona Doctor Josep Trueta /ID# 202040
🇪🇸Girona, Spain
Hospital Juan Ramon Jimenez /ID# 171243
🇪🇸Huelva, Spain
Hospital Universitario Virgen Macarena /ID# 171240
🇪🇸Sevilla, Spain
Hospital Universitario y Politecnico La Fe /ID# 201988
🇪🇸Valencia, Spain
Hallands Hospital Halmstad /ID# 170840
🇸🇪Halmstad, Hallands Lan, Sweden
Alingsas lasarett /ID# 170838
🇸🇪Alingsas, Vastra Gotalands Lan, Sweden
Sahlgrenska University Hospital /ID# 169031
🇸🇪Gothenburg, Vastra Gotalands Lan, Sweden
Universitätsspital Zürich /ID# 170999
🇨🇭Zürich, Zuerich, Switzerland
Inselspital, Universitätsspital Bern /ID# 171006
🇨🇭Bern, Switzerland
Linkou Chang Gung Memorial Ho /ID# 169788
🇨🇳Taoyuan City, Taiwan
Acibadem Kozyatagi Hospital /ID# 209405
🇹🇷Kadikoy, Istanbul, Turkey
Erciyes University Medical Fac /ID# 171321
🇹🇷Melikgazi, Kayseri, Turkey
Ankara Univ Medical Faculty /ID# 206412
🇹🇷Ankara, Turkey
Mustafa Kemal University Medic /ID# 171318
🇹🇷Hatay, Turkey
Inonu Universitesi Turgut Ozal /ID# 201267
🇹🇷Battalgazi/malatya, Turkey
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 200280
🇹🇷Istanbul, Turkey
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171316
🇹🇷Istanbul, Turkey
Sisli Etfal Train & Res Hosp /ID# 171317
🇹🇷Sisli, Turkey
Gazi Universitesi Tip Fakultes /ID# 217443
🇹🇷Yenimahalle, Turkey
South Eastern Health and Social Care Trust /ID# 205322
🇬🇧Belfast, Antrim, United Kingdom
Warrington and Halton Hospitals NHS Foundation Trust /ID# 209085
🇬🇧Warrington, Cheshire West And Chester, United Kingdom
Royal United Hospitals Bath /ID# 169084
🇬🇧Bath, United Kingdom
Barts Health NHS Trust /ID# 218829
🇬🇧London, London, City Of, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 169080
🇬🇧Birmingham, United Kingdom
London North West University Healthcare NHS Trust /ID# 169078
🇬🇧Harrow, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169085
🇬🇧Newcastle Upon Tyne, United Kingdom
Stockport NHS foundation trust /ID# 208718
🇬🇧Stockport, United Kingdom
Taunton and Somerset NHS Foundation Trust /ID# 209664
🇬🇧Taunton, United Kingdom
St George's University Hospitals NHS Foundation Trust /ID# 205551
🇬🇧Tooting, United Kingdom
The Royal Wolverhampton NHS Trust /ID# 171387
🇬🇧Wolverhampton, United Kingdom
Sodra Alvsborgs sjukhus /ID# 202889
🇸🇪Boras, Vastra Gotalands Lan, Sweden
The Dudley Group NHS Foundation Trust /ID# 169079
🇬🇧Dudley, United Kingdom
Policlinico San Martino/Univer /ID# 168177
🇮🇹Genova, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 200008
🇮🇹Modena, Italy
CHRU Tours - Hopital Trousseau /ID# 169786
🇫🇷Chambray Les Tours, France
Polyclinique Grand Sud /ID# 170649
🇫🇷Nimes Cedex, France
Medicor Research Inc /ID# 166967
🇨🇦Sudbury, Ontario, Canada
Kaiser Clinica e Hospital Dia /ID# 166873
🇧🇷Sao Jose Do Rio Preto, Sao Paulo, Brazil
Mayo Clinic - Rochester /ID# 164868
🇺🇸Rochester, Minnesota, United States
Quality Clinical Research Inc. /ID# 170177
🇺🇸Omaha, Nebraska, United States
CHI Health Research Center /ID# 168545
🇺🇸Omaha, Nebraska, United States
Froedtert Memorial Lutheran Hospital /ID# 202286
🇺🇸Milwaukee, Wisconsin, United States
Hospital Universitario La Paz /ID# 171241
🇪🇸Madrid, Spain
Kangbuk Samsung Hospital /ID# 167577
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Advanced Research Institute /ID# 164866
🇺🇸Ogden, Utah, United States
The Mount Sinai Hospital /ID# 170172
🇺🇸New York, New York, United States
Lahey Hospital and Medical Center /ID# 214725
🇺🇸Burlington, Massachusetts, United States
Texas Digestive Disease Consultants /ID# 209952
🇺🇸Cedar Park, Texas, United States
Gastro Health & Nutrition - Victoria /ID# 167813
🇺🇸Victoria, Texas, United States
CliniCore International, LLC /ID# 164662
🇺🇸Houston, Texas, United States
Caprock Gastro Research /ID# 215437
🇺🇸Lubbock, Texas, United States
Carl R. Meisner Medical Clinic /ID# 201060
🇺🇸Sugar Land, Texas, United States
Tyler Research Institute, LLC /ID# 168681
🇺🇸Tyler, Texas, United States
Clinical Research Trials of Florida, Inc. /ID# 203484
🇺🇸Tampa, Florida, United States
AdventHealth Tampa /ID# 171175
🇺🇸Tampa, Florida, United States
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 166874
🇧🇷Ribeirão Preto, Sao Paulo, Brazil
Assaf Harofeh Medical Center /ID# 204870
🇮🇱Be'Er Ya'Akov, Israel
Omega Research Maitland, LLC /ID# 203480
🇺🇸Orlando, Florida, United States
Endoscopic Research, Inc. /ID# 205893
🇺🇸Orlando, Florida, United States
University of Louisville /ID# 168536
🇺🇸Louisville, Kentucky, United States
University of Louisville /ID# 208093
🇺🇸Louisville, Kentucky, United States
University of Michigan Health Systems /ID# 164844
🇺🇸Ann Arbor, Michigan, United States
Wake Forest Baptist Medical Center /ID# 201225
🇺🇸Winston-Salem, North Carolina, United States
Pharmacorp Clinical Trials /ID# 164809
🇺🇸Charleston, South Carolina, United States
Hospital Italiano de Buenos Aires /ID# 215543
🇦🇷Ciudad Autonoma Buenos Aires, Ciuadad Autonoma De Buenos Aires, Argentina
Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217841
🇧🇦Sarajevo, Bosnia and Herzegovina
UHC Split /ID# 171206
🇭🇷Split, Croatia
CHU Bordeaux - Hopital Haut Lévêque /ID# 207414
🇫🇷Pessac CEDEX, Gironde, France
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202103
🇬🇷Athens, Attiki, Greece
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205546
🇭🇺Miskolc, Borsod-Abauj-Zemplen, Hungary
Rabin Medical Center /ID# 202635
🇮🇱Petakh Tikva, Israel
Nagoya University Hospital /ID# 165955
🇯🇵Nagoyashi, Aichi, Japan
Delsol Research Management, Ll /Id# 170179
🇺🇸Chandler, Arizona, United States
Kaplan Medical Center /ID# 170277
🇮🇱Rehovot, Israel
Cemic /Id# 169184
🇦🇷Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Hospital Privado Univesitario /ID# 169228
🇦🇷Cordoba, Argentina
Hospital San Vicente de Paul /ID# 200028
🇨🇴Medellin, Antioquia, Colombia
Clinical Hospital Dubrava /ID# 171186
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 171201
🇭🇷Zagreb, Grad Zagreb, Croatia
Tartu University Hospital /ID# 203140
🇪🇪Tartu Linn, Tartumaa, Estonia
Chu de Nice-Hopital L'Archet Ii /Id# 171009
🇫🇷Nice, Alpes-Maritimes, France
CHU Amiens-Picardie Site Sud /ID# 171016
🇫🇷Amiens CEDEX 1, Somme, France
Tzaneio general hospital of Piraeus /ID# 206432
🇬🇷Piraeus, Attiki, Greece
HonorHealth Research Institute - Shea /ID# 164734
🇺🇸Scottsdale, Arizona, United States
Air Force Specialized Hospital /ID# 170995
🇪🇬Cairo, Egypt
AGA Clinical Research Associates, LLC /ID# 164883
🇺🇸Egg Harbor Township, New Jersey, United States
UCL Saint-Luc /ID# 200297
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
CHU de SAINT ETIENNE - Hopital Nord /ID# 171018
🇫🇷St. Priest En Jarez, Loire, France
Obudai Egeszsegugyi Centrum Kft. /ID# 201891
🇭🇺Budapest, Pest, Hungary
Mercy University Hospital /ID# 206510
🇮🇪Cork, Ireland
Soroka University Medical Center /ID# 169912
🇮🇱Be'er Sheva, HaDarom, Israel
Asahikawa Medical University Hospital /ID# 167133
🇯🇵Asahikawa-shi, Hokkaido, Japan
Aoyama Clinic /ID# 166001
🇯🇵Kobe-shi, Hyogo, Japan
Yokkaichi Hazu Medical Center /ID# 167191
🇯🇵Yokkaichi-shi, Mie, Japan
Japanese Red Cross Wakayama Medical Center /ID# 200638
🇯🇵Wakayama-shi, Wakayama, Japan
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170225
🇵🇹Guimaraes, Braga, Portugal
University of Catanzaro /ID# 201920
🇮🇹Catanzaro, Calabria, Italy
Clinical Center Vojvodina /ID# 168222
🇷🇸Novi Sad, Vojvodina, Serbia
Kyorin University Hospital /ID# 165950
🇯🇵Mitaka-shi, Tokyo, Japan
UMHAT Kaspela EOOD /ID# 167617
🇧🇬Plovdiv, Bulgaria
Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 201720
🇭🇺Debrecen, Hungary
Nagoya City University Hospital /ID# 165956
🇯🇵Nagoya shi, Aichi, Japan
Toho University Sakura Medical Center /ID# 165949
🇯🇵Sakura-shi, Chiba, Japan
NHO Fukuyama Medical Center /ID# 167139
🇯🇵Fukuyama-shi, Hiroshima, Japan
Niigata University Medical & Dental Hospital /ID# 170044
🇯🇵Niigata-shi, Niigata, Japan
Toyama Prefectural Central Hospital /ID# 217833
🇯🇵Toyama-shi, Toyama, Japan
Centrum Zdrowia MDM /ID# 200486
🇵🇱Warszawa, Mazowieckie, Poland
University Clinical Center Kragujevac /ID# 205858
🇷🇸Kragujevac, Sumadijski Okrug, Serbia
Southern Therapy and Advanced Research (STAR) LLC /ID# 165318
🇺🇸Jackson, Mississippi, United States
Radboud Universitair Medisch Centrum /ID# 166925
🇳🇱Nijmegen, Gelderland, Netherlands
Zuyderland Medisch Centrum /ID# 169698
🇳🇱Heerlen, Limburg, Netherlands
Faculty of Medicine Ain Shams Research Institute- Clinical Research Centre /ID# 209565
🇪🇬Cairo, Egypt
Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207143
🇲🇽Victoria de Durango, Durango, Mexico
Hyogo College of Medicine College Hospital /Id# 200173
🇯🇵Nishinomiya-shi, Hyogo, Japan
Sameshima Hospital /ID# 206674
🇯🇵Kagoshima-shi, Kagoshima, Japan
Ishida Clinic of IBD and Gastroenterology /ID# 167134
🇯🇵Oita-shi, Oita, Japan
Osaka Medical and Pharmaceutical University Hospital /ID# 206324
🇯🇵Takatsuki-shi, Osaka, Japan
Tokyo Medical And Dental University, Medical Hospital /ID# 165948
🇯🇵Bunkyo-ku, Tokyo, Japan
Duplicate_Tokai University Hachioji Hospital /ID# 165951
🇯🇵Hachioji-shi, Tokyo, Japan
Malopolskie Centrum Kliniczne /ID# 202166
🇵🇱Krakow, Malopolskie, Poland
Kazan State Medical University /ID# 169574
🇷🇺Kazan, Tatarstan, Respublika, Russian Federation
X7 Clinical Research Center /ID# 216349
🇷🇺Saint Petersburg, Russian Federation
Univ Medical Ctr Ljubljana /ID# 211042
🇸🇮Ljubljana, Slovenia
Yamagata University Hospital /ID# 200156
🇯🇵Yamagata-shi, Yamagata, Japan
Vilnius University Hospital Santaros Klinikos /ID# 203285
🇱🇹Vilnius, Lithuania
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170778
🇲🇾Kuala Lumpur, Selangor, Malaysia
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202988
🇷🇺Perm, Permskiy Kray, Russian Federation
University Clinical Center Serbia /ID# 168220
🇷🇸Belgrade, Beograd, Serbia
National Taiwan University Hospital /ID# 169789
🇨🇳Taipei City, Taiwan
University of Calgary - Cumming School of Medicine - Adult Cystic Fibrosis Clini /ID# 166963
🇨🇦Calgary, Alberta, Canada
Farmovs (Pty) Ltd /Id# 207536
🇿🇦Bloemfontein, Free State, South Africa
The Vancouver Clinic, INC. PS /ID# 164811
🇺🇸Vancouver, Washington, United States
Tokyo Women's Medical University Hospital /ID# 205981
🇯🇵Shinjuku-ku, Tokyo, Japan
King's College Hospital NHS Foundation Trusts /ID# 169082
🇬🇧London, United Kingdom
Hospital Sultanah Bahiyah /ID# 202627
🇲🇾Alor Setar, Kedah, Malaysia
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 206779
🇲🇽Guadalajara, Jalisco, Mexico
Sun Yat-sen Memorial Hospital of Sun Yat-sen University /ID# 205226
🇨🇳Guangzhou, Guangdong, China
The Sixth Affiliated Hosp Sun /ID# 204049
🇨🇳Guangzhou, Guangdong, China
Queen Mary Hospital /ID# 171217
🇭🇰Hong Kong, Hong Kong