NCT00707603已完成不适用
Understanding the Relationship Between Insulin Resistance and Chronic Hepatitis C Infection
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Insulin Resistance by euglycaemic hyperinsulinaemic clamp Liver fat, abdominal fat and muscle fat measures
研究概览
简要总结
Chronic hepatitis C (CHC) is among the commonest chronic infectious disease in Australia with >200,000 exposed persons. Amongst non-infectious chronic conditions- Type 2 diabetes, obesity and heart disease are extremely common. This study will examine the relationship between insulin resistance, fat deposition in the liver, muscle and abdomen, and liver injury due to CHC
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Caucasian male
- •Age: 25-55 years
- •Chronic Hepatitis C (PCR positive) and fibrosis ≤ F2 (if liver biopsy done)
- •Genotypes 1 or 3
- •Due to commence antiviral therapy
- •BMI < 30
排除标准
- •Cirrhosis or F3 fibrosis on liver biopsy (if done)
- •> 20 g ETOH per day
- •Type 2 Diabetes (need an OGTT if fasting BGL> 5.7)
- •Concurrent HIV
- •Other cause of liver disease
结局指标
主要结局
Insulin Resistance by euglycaemic hyperinsulinaemic clamp Liver fat, abdominal fat and muscle fat measures
时间窗: 2 years
次要结局
- insulin resistance post treatment of Hep C(2 years)
研究者
Dr Jerry Greenfield
Head of Endocrinology Department St Vincent's Hospital Sydney
Garvan Institute of Medical Research
研究点 (2)
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