The effects of depth of anaesthesia and blood pressure on motor evoked potentials inspinal surgery.
Completed
- Conditions
- disease of the spinal colomnspinal pathology for which spinal surgery is indicated10041543
- Registration Number
- NL-OMON48128
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
All >= 12 years
Patient is diagnosed with spinal pathology for which surgery with the use of
intraoperative neurophysiological monitoring has been planned
Signed and dated informed consent document prior to any study-related
procedures
Exclusion Criteria
Patient refusal
Existing motor weakness in the tibialis anterior muscle left or right, the
gastrocnemius muscle left or right and the abductor hallucis muscle left or
right.
Patients with epilepsy
Patients with a pacemaker
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Part 1:<br /><br>The main study parameter of part 1 is to investigate the effect of depth of<br /><br>anaesthesia, defined by different pEEG values (30, 40 and 50), on Tc-MEP<br /><br>voltage thresholds, Tc-MEP amplitude and Tc-MEP AUC of the leg muscles.<br /><br><br /><br>Part 2:<br /><br>The main study parameter of part 2 is to investigate the effect of elevating<br /><br>MAP from 60 to 100 with a vasopressor infusion, on Tc-MEP voltage thresholds,<br /><br>Tc-MEP amplitude and Tc-MEP AUC of the leg muscles.<br /><br>*</p><br>
- Secondary Outcome Measures
Name Time Method