Research on the Application of Electrical Impedance Tomography in Bronchial Challenge Testing

Not yet recruiting

• Conditions: Asthma

• Registration Number: NCT06502405
• Lead Sponsor: wang kaifei

Brief Summary

The purpose of this study was to examine whether electrical impedance tomography (EIT) was capable of identifying the deteriorated lung function on a regional level during bronchial challenge testing and whether EIT may provide additional information during bronchial challenge testing and identify spatial and temporal heterogeneity of regional lung function.

Detailed Description

The content of this study includes:

1. Can EIT identify the uneven ventilation caused by airway contraction in patients during bronchial provocation tests.

2. Can EIT monitor airway contraction in patients before Spirometer examination after inhaling activators.

3. Can EIT observe uneven ventilation caused by airway contraction through tidal breathing after the patient inhales activator.

Study Timeline

• Status Verified: 2024-07
• Study First Submitted: 2024-07-09
• Study First Submitted QC: 2024-07-09
• Last Update Submitted: 2024-07-09
• Study First Posted: 2024-07-16
• Last Update Posted: 2024-07-16
• Study Start: 2024-08-01
• Primary Completion: 2024-12-31
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

1. patients with a pre-bronchodilator FEV1≤60% predicted.

2. Contraindications for bronchial challenge testing.

3. Pregnant or lactating women.

4. After pacemaker surgery.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
global inhomogeneity index （GI）	1day	Measured by EIT, used to describe the overall degree of spatial heterogeneity of ventilation.
forced expiratory volume in 1s (FEV1)	1day	The forced expiratory volume in 1s measured during pulmonary function tests.