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Clinical Trials/NCT03474250
NCT03474250
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Trans-catheter Aortic Valve Replacement and Renal Infarction Among Patients With Severe Aortic Stenosis

Sheba Medical Center1 site in 1 country20 target enrollmentApril 1, 2018
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ConditionsRenal Infarction

Overview

Phase
N/A
Intervention
Not specified
Conditions
Renal Infarction
Sponsor
Sheba Medical Center
Enrollment
20
Locations
1
Primary Endpoint
New Renal Infarction
Last Updated
8 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Kidney Magnetic Resonance assessment before and after undergoing transcatheter aortic valve replacement

Detailed Description

Each patient will undergo Magnetic Resonance assessment of the kidneys before the TAVR. on the third to 7th day after the ATVR, a second MRI to the kidneys will be performed. we will assess the changes and new lesions between both MRI tests and will perform a qualitative and quantitative measurement.

Registry
clinicaltrials.gov
Start Date
April 1, 2018
End Date
December 31, 2018
Last Updated
8 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Prof. Amit Segev

Proffesor

Sheba Medical Center

Eligibility Criteria

Inclusion Criteria

  • •Severe symptomatic aortic stenosis
  • •Patient is able to lay down supine for 20 min (the time needed to perform the MRI) without any difficulties.

Exclusion Criteria

  • •Patient is on chronic renal replacement therapy (Dialysis)
  • •Documented Thrombus in the left ventricle or left atria

Outcomes

Primary Outcomes

New Renal Infarction

Time Frame: one year

New low signal intensity lesions on diffusion weighted images on MRI.

Secondary Outcomes

  • Hematuria(one year)
  • Elevation in Blood Pressure(one year)
  • Elevation in Plasma Renin Activity(one year)
  • Elevation in Aldosteron level(one year)

Study Sites (1)

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