NCT03474250Unknown不适用
Trans-catheter Aortic Valve Replacement and Renal Infarction Among Patients With Severe Aortic Stenosis
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- New Renal Infarction
研究概览
简要总结
Kidney Magnetic Resonance assessment before and after undergoing transcatheter aortic valve replacement
详细描述
Each patient will undergo Magnetic Resonance assessment of the kidneys before the TAVR. on the third to 7th day after the ATVR, a second MRI to the kidneys will be performed. we will assess the changes and new lesions between both MRI tests and will perform a qualitative and quantitative measurement.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe symptomatic aortic stenosis
- •Patient is able to lay down supine for 20 min (the time needed to perform the MRI) without any difficulties.
排除标准
- •Patient is on chronic renal replacement therapy (Dialysis)
- •Documented Thrombus in the left ventricle or left atria
结局指标
主要结局
New Renal Infarction
时间窗: one year
New low signal intensity lesions on diffusion weighted images on MRI.
次要结局
- Hematuria(one year)
- Elevation in Blood Pressure(one year)
- Elevation in Plasma Renin Activity(one year)
- Elevation in Aldosteron level(one year)
研究者
Prof. Amit Segev
Proffesor
Sheba Medical Center
研究点 (1)
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