Brain Biomarkers as Response Predictors to Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder: development of a paradigm towards personalized medicine

Instituto de Psiquiatria0 个研究点开始时间: 2022年3月15日最近更新: 2023年5月29日

适应症

试验速览

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•Male or female aged between 18 and 50 years; Main diagnosis of Obsessive-Compulsive Disorder according to DSM-5; Y-BOCS score = 16; No psychotropic medication used in the last 6 weeks; No behavioral therapy or response prevention exposure focusing on Obsessive-Compulsive Disorder in the past 6 weeks; Able to tolerate a 1-week treatment-free period; and Able to provide informed consent.

•Lifetime diagnosis of psychotic disorder, bipolar disorder, anorexia nervosa, autistic spectrum disorder with IQ<80, Tourette's disorder; Current chronic tic disorder (current = within the last 12 months); Disorders related to the use of current substances, including nicotine (current = within the last 12 months); Current eating disorder or bulimia (current = within the last 12 months); Acute risk of suicide. Pregnant women; Medical or neurological problems (including head trauma with loss of consciousness); Presence of metal devices on the body or dental appliances; IQ<80; Cigarette use: more than 5 per day; Alcohol use: more than 2 drinks a day for women
•and more than 3 drinks a day for men; Cannabis use: more than once a week.

发起方

Instituto de Psiquiatria