Open Lung Approach Versus Standard Protective Strategies

Not Applicable

Completed

• Conditions: Lung Collapse
• Interventions: Procedure: RM-5; Procedure: OLA

• Registration Number: NCT02798133
• Lead Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia

Brief Summary

The aim of this study was to compare the effects of adding a recruitment maneuver (RM) to low tidal volume (VT) ventilation, with or without an individualized post-RM positive end-expiratory pressure (PEEP) setting in lung-healthy patients during anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-07
• Primary Completion: 2014-10
• Study Completion: 2014-11
• Study First Submitted: 2016-06-05
• Study First Submitted QC: 2016-06-08
• Study First Posted: 2016-06-14
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-25
• Last Update Posted: 2017-04-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• ASA physical status I-III undergoing elective major abdominal surgery including pancreatic-duodenectomy, gastrectomy and liver resection

Exclusion Criteria

• i) laparoscopic surgery, ii) patients with previous respiratory disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RM-5	RM-5	recruitment maneuver + fixed standard PEEP
OLA	OLA	recruitment maneuver + individualized PEEP

Primary Outcome Measures

Name	Time	Method
driving pressure	intraoperative	The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications

Secondary Outcome Measures

Name	Time	Method
ventilatory efficiency	intraoperative	Ventilatory efficiency measured with volumetric capnography which includes dead space and tidal elimination of carbon dioxide.