Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions

Not Applicable

Not yet recruiting

• Conditions: Knee Osteoarthritis
• Interventions: Procedure: stromal vascular fraction injection in the osteoarthritic knee

• Registration Number: NCT06000670
• Lead Sponsor: Dubai Health Authority

Brief Summary

clinical efficacy of autologous stromal vascular fraction SVF,for inflammatory and degenerative conditions of the knees

Detailed Description

to evaluate the clinical effectiveness of point of care autologous adipose derived stromal vascular fraction (SVF) alone or in combination with exosomes,for inflammatory and degenerative conditions of the knees.

Study Timeline

• Study First Submitted: 2023-08-02
• Study First Submitted QC: 2023-08-17
• Study First Posted: 2023-08-21
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-20
• Last Update Posted: 2024-02-21
• Study Start: 2024-12-30
• Primary Completion: 2026-06-01
• Study Completion: 2026-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• knee osteoarthritis any grade

  • knee chondromalacia grade 2 and above

Exclusion Criteria

• active HIV
• pregnant women
• Mental disease
• severe cardio vascular disease
• severe coagulation disorders
• infected tissues
• patients on other experimental studies within 3 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
knee osteoarhritis	stromal vascular fraction injection in the osteoarthritic knee	patients with grade 2 and above chondromlacia as well as all grades of osteoarhtritis

Primary Outcome Measures

Name	Time	Method
change in pain level	2 years	visual analog scale 0-10 ( 10 being worst)

Secondary Outcome Measures

Name	Time	Method
percentage cartilage thickness change	2 years	as measured by MRI