ISRCTN03683971已完成未知
The role of striatal serotonergic terminals in L-dopa induced-dyskinesia in Parkinson's disease patients: a proof of concept study
Imperial College London (UK)0 个研究点目标入组 300 人开始时间: 2012年7月31日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Parkinson's disease patients and healthy individuals
- •Parkinson's disease patients
- •1. Age between 50-80
- •2. Were diagnosed with PD according to the UK PD Society Brain Bank criteria (Hughes et al., 1992)
- •3. On L-dopa treatment during the time of the study
- •4. Responsive to L-dopa with more than 25% reductions in Unified PD Rating Scale (UPDRS) part III motor scores
- •5. More than 6 months on L-DOPA
- •6. Non-demented [mini?mental state examination (MMSE = 26]
- •7. No psychiatric disorders as screened with a structured clinical interview for DSM-IV Axis I Disorders (SCID-I)
- •8. Do not fail screening for depression [Beck Depression Inventory - II (BDI-II) < 17; Hamilton Rating Scale for Depression (HRSD) < 14]
- •9. None of the subjects had received anti-depressant therapy in the past or any other medication with known action on the serotonergic system
- •10. No more than 1.5 body mass index (BMI) units changes over the last 12 months
- •Healthy individuals
- •1. Age between 50-80
- •2. Non-demented (MMSE = 26)
- •3. No psychiatric disorders as screened with a structured clinical interview for DSM-IV Axis I Disorders (SCID-I)
- •4. Do not fail screening for depression (BDI-II < 17; HRSD < 14)
- •5. None of the subjects had received anti-depressant therapy in the past or any other medication with known action on the serotonergic system
- •6. No more than 1.5 BMI units changes over the last 12 months
- •7. Were not on any medication
- •8. No previous history of neurological or psychiatric illness
排除标准
- •Does not meet inclusion criteria
研究者
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