跳至主要内容
临床试验/NCT06029751
NCT06029751招募中不适用

Dynamic Follow-up of Factors Influencing Implant Success and Models for Predicting Implant Outcomes

The Dental Hospital of Zhejiang University School of Medicine1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2017年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
1,000
试验地点
1
主要终点
Mean Bone Level of dental implant

研究概览

简要总结

Nowadays, artificial intelligence technology with machine learning as the main means has been increasingly applied to the oral field, and has played an increasingly important role in the examination, diagnosis, treatment and prognosis assessment of oral diseases. Among them, machine learning is an important branch of artificial intelligence, which refers to the system learning specific statistical patterns in a given data set to predict the behavior of new data samples [8]. Machine learning is divided into two main categories: Supervised learning and Unsupervised learning. Whether there is supervision depends on whether the data entered is labeled or not. If the input data is labeled, it is supervised learning. Unlabeled learning is unsupervised. Supervised learning is a kind of learning algorithm when the correct output of the data set is known. Because the input and output are known, it means that there is a relationship between the input and output, and the supervised learning algorithm is to discover and summarize this "relationship". Unsupervised learning refers to a class of learning algorithms for unlabeled data. The absence of label information means that patterns or structures need to be discovered and summarized from the data set.

详细描述

Starting from different data types, researchers built a variety of models to mine the data itself and predict the prognosis of the implant. Machine learning is often more impressive and intuitive in terms of images. In the field of oral implantology, researchers analyze preoperative image data based on machine learning to identify important anatomical structures (such as maxillary sinus, mandibular neural tube, etc.) and analyze alveolar bone quality. Large-scale imaging data is also used to identify the different implant systems on the market. Machine learning also plays an important role in the development of implant surgery plans, which is conducive to more accurate and efficient implantation surgery. The evaluation of implant retention rate and individual bone level is also one of the key clinical concerns. Most methods to study such issues are: Kaplan-Meier survival analysis, Cox survival analysis, etc., to study implant retention rate and influencing factors. Linear (mixed) model and multiple logistic regression were used to study the changes and influencing factors of bone absorption at implant edge. However, in daily clinical practice, there may be some practical problems such as lost follow-up and partial data missing. As the clinical scenarios of research become more and more clear, even partial data missing often leads to results that cannot be accurately evaluated and predicted. Therefore, in terms of supervised learning, this study aims to establish a predictive model of implant bone level change and evaluate the accuracy of the model through machine learning of implant edge bone level (MBL) with large amounts of data. In terms of unsupervised learning, the aim is to identify susceptibility phenotypes to implant failure through: clustering of individual-related information about implants.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged 18 years and above;
  • 1-5 years after implantation;
  • Implantation torque > 35N·cm;
  • Signed informed consent.

排除标准

  • Contraindications of general implantation surgery;
  • Have received head and neck radiation therapy;
  • Past or current treatment with bisphosphonates;
  • Do not cooperate with the interviewer.

结局指标

主要结局

Mean Bone Level of dental implant

时间窗: 1-7 years

The vertical distance between the implant and the first contact area of bone and the tip of the implant (mesial and distal)

次要结局

未报告次要终点

研究者

发起方
The Dental Hospital of Zhejiang University School of Medicine
申办方类型
Other
责任方
Principal Investigator
主要研究者

Yi Zhou

Deputy Chief Physician, Deputy Director of Dental Implant Department

The Dental Hospital of Zhejiang University School of Medicine

研究点 (1)

Loading locations...

相似试验