Patogenic Mutation in 5 Genes

Completed

• Conditions: Colorectal Cancer; TP53 Gene Mutation; PIK3CA Gene Mutation; APC Gene Mutation; KRAS Mutation-Related Tumors; MLH1 Gene Mutation
• Interventions: Other: co-occuring mutation

• Registration Number: NCT04976439
• Lead Sponsor: Dr Cipto Mangunkusumo General Hospital

Brief Summary

This is a pathogenic mutation profile of colorectal patients specifically in 5 genes, i.e. APC, TP53, PIK3CA, KRAS, and MLH1. Single nucleotide variants identified were synchronized with patients' characteristics.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-01
• Primary Completion: 2021-06-10
• Study Completion: 2021-06-14
• Status Verified: 2021-07
• Study First Submitted: 2021-07-02
• Study First Submitted QC: 2021-07-21
• Last Update Submitted: 2021-07-21
• Study First Posted: 2021-07-26
• Last Update Posted: 2021-07-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• FFPE samples fullfilling purity criterion and pass quality control

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Tumor location	co-occuring mutation	-
Stage	co-occuring mutation	-
Age	co-occuring mutation	-
Grade	co-occuring mutation	-
Lymphovascular invasion	co-occuring mutation	-

Primary Outcome Measures

Name	Time	Method
Description of survival	January 2017 - June 2021	Median of life expectancy
Description of clinical characteristics	January 2017 - June 2021	Age, gender
Description of tumor nature	January 2017 - June 2021	grade, stage, lymphovascular invasion, tumor location

Trial Locations

Locations (1)

Vania Myralda Giamour Marbun; 🇮🇩 Jakarta, ALL, Indonesia