Efficacy and safety of dobutamine infusion for exclusion of left atrial appendage thrombus in patients with severe spontaneous echo contrast caused by atrial fibrillation

Machino Tomoko0 个研究点目标入组 20 人开始时间: 2022年12月27日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•Inclusion criteria for the first step
•1)Patients with valvular or non-valvular atrial fibrillation (AF)
•2)Patients undergoing transesophageal echocardiography (TEE) for evaluation of intracardiac thrombus before catheter ablation for AF, percutaneous left atrial appendage (LAA) occlusion, percutaneous mitral valve commissurotomy, and electrical cardioversion, or patients suspected cardiogenic stroke and undergoing TEE to evaluate intracardiac thrombus
•3)Patients with a CHADS2 score of 1 or higher
•4)Patients receiving anticoagulant therapy
•5)Men and women over 20 years old
•6)Patients with written informed consent
•Inclusion criteria for the second step
•7)Patients with severe blood flow stasis (spontaneous echo contrast grade of 3 or 4) in left atrium (LA) and LAA

•Exclusion criteria for the first step
•1) Patients with past history of LAA occlusion or resection
•2) Patients with systolic blood pressure of 80 mmHg or less or 180 mmHg or more before the start of TEE
•3) Patients with heart rate (measured by the average method) of 100 bpm or more before the start of TEE
•4) Patients receiving catecholamines
•5) Patients with a history of allergic reactions to dobutamine
•6) Patients with hypertrophic cardiomyopathy who have intraventricular obstruction with a maximum pressure gradient of 30 mmHg or more
•7) Patients with unstable angina
•8) Patients with disorientation, quadriplegia, dysarthria, and visual field impairment
•9) Women who are pregnant or may become pregnant
•10) Patients who are judged inappropriate by the researcher
•Exclusion criteria for the second step
•11) Patients with obvious LAA thrombus without infusion of dobutamine
•12) Patients with systolic blood pressure of 80 mmHg or less or 180 mmHg or more before the start of dobutamine infusion
•13) Patients with heart rate (measured by the average method) of 100 bpm or more before the start of dobutamine infusion

发起方

Machino Tomoko