euronal correlates of post-stroke epilepsy and the associated cognitive impairment - PoSECI-7T

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 72 人开始时间: 待定最近更新: 2024年4月23日

试验速览

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•- Patients suffering from stroke (and post-stroke epilepsy), including both brain infarction, cerebral hemorrhage and clinically significant hemorrhagic transformation of stroke (or a primary intracerebral hemorrhage)
•- Patients suffering from post-stroke epilepsy after cortical stroke defined as one or more unprovoked epileptic seizures occurring more than one week after the stroke, according to International League Against Epilepsy criteria.
•- Patients suffering from cortical stroke, with the onset of acute stroke symptoms more than 4 months prior to inclusion.
•- Age > 18 years

•-onset of stroke (and epilepsy for post-stroke epilepsy patients) less than 4 months ago
•-In case of the PSE group: onset of epilepsy within a week or 2 years after the onset of stroke.
•-previous history of epilepsy
•-history of another cerebral disorder (neurodegenerative diseases, tumours)
•-inability to provide informed consent
•- any contraindication for MRI: metallic foreign body, pacemaker, claustrophobia, pregnancy, tattoos, permanent make-up.
•- known contrast allergy to gadolinium, insufficient kidney function (eGFR<=30).
•- A history of topiramate use as an anti-epileptic drug, because of its known cognitive effects.

发起方

Medisch Universitair Ziekenhuis Maastricht