Performance of Pulmonary Embolism Risk Scores Out Come in CTPA Confirmed Patients

Not yet recruiting

• Conditions: Pulmonary Embolism

• Registration Number: NCT05613855
• Lead Sponsor: Assiut University

Brief Summary

1. Assess performance of PERFORM score in predicting outcome in CTPA confirmed patients.

2. Compare PERFORM score with the currently validated PESI in risk stratification of patients

Detailed Description

Pulmonary embolism (PE) is a common and potentially lethal condition in the emergency department requiring early and accurate management.

The short-term mortality rate of PE varies widely and ranges from less than 2% in many patients with non massive PE to more than 95% in patients who experience cardiorespiratory arrest.

Although several prognostic models of acute PE are currently used, all of them have practical limitations.

Of all clinical scores integrating PE severity and comorbidity, the Pulmonary Embolism Severity Index (PESI) and its simplified version,(sPESI) have been most extensively validated to date.

However, current prognostic scores for pulmonary embolism (PE) are partly based on patients without PE confirmation via computed tomographic pulmonary angiography (CTPA), involving subjective parameters and complicated scoring methods \[8\].

Therefore, an objective, accurate, and simple prognostic model in CTPA-confirmed patients to predict the risk of 30-day mortality. help clinicians assess patients' risks and improve therapeutic decision-making that is called PERFORM score (pulmonary embolism risk score for mortality)

Study Timeline

• Status Verified: 2022-11
• Study Start: 2022-11
• Study First Submitted: 2022-11-07
• Study First Submitted QC: 2022-11-07
• Last Update Submitted: 2022-11-07
• Study First Posted: 2022-11-14
• Last Update Posted: 2022-11-14
• Primary Completion: 2024-04
• Study Completion: 2024-04

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients above 18 years old with PE confirmed by CTPA are considered for inclusion in the study.

Exclusion Criteria

• • Patients who have contraindications for CTPA eg. Renal impairment

  • Patients diagnosed and treated as PE without doing CTPA.
  • Patients who refuse to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess performance of PERFORM score in predicting outcome in CTPA confirmed patients.	from 11/2022 to 4/2024

Secondary Outcome Measures

Name	Time	Method
Compare PERFORM score with the currently validated PESI in risk stratification of patients.	from 11/2022 to 4/2024