NCT01055717已完成不适用
Bioavailability of Avenanthramide-Enriched Oats in Healthy Older Adults
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Levels of avenanthramides and their in vivo metabolites in blood, urine, and feces following the consumption of avenanthramide-enriched oats delivered in a baked muffin
研究概览
简要总结
This is a placebo-controlled, crossover study investigating the pharmacokinetic bioavailability of avenanthramides from avenanthramide-enriched oats and their in vivo metabolites in a cohort of healthy, older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and postmenopausal women
- •BMI 18.5-29.9 kg/m2
排除标准
- •Cigarette smoking and/or nicotine replacement use
- •Use of cholesterol-lowering medications
- •Use of blood pressure-lowering medications
- •Use of any stomach acid-lowering medications
- •Cardiovascular (heart) disease
- •Gastrointestinal disease
- •Kidney disease
- •Endocrine disease: including diabetes, untreated thyroid disease
- •Rheumatoid arthritis
- •Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- •Systolic blood pressure > 150 mm Hg and/or diastolic blood pressure > 95 mm Hg
- •Regular use of oral steroids
- •Regular daily intake of 2 or more alcoholic drinks
- •Illicit drug use
- •No fish oil supplements (including cod liver oil) for one month prior to study admission
- •No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission
研究组 & 干预措施
Placebo muffin made with no oats
Placebo Comparator
干预措施: Avenanthramide-enriched oats (Other)
Test muffin made with AV-enriched oats
Active Comparator
干预措施: Avenanthramide-enriched oats (Other)
结局指标
主要结局
Levels of avenanthramides and their in vivo metabolites in blood, urine, and feces following the consumption of avenanthramide-enriched oats delivered in a baked muffin
时间窗: 24 hours
次要结局
未报告次要终点
研究者
研究点 (1)
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