Plasma B-Type Natriuretic Peptide Concentrations in Preterm Infants < 28 Weeks
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 82
- Locations
- 1
Study Overview
Brief Summary
The aim of the study was to evaluate BNP in preterm infants < 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not. We hypothesized that high plasma BNP concentrations on day 2 are associated with the need of PDA intervention in the further course.
Detailed Description
From the study infants blood samples (0.1ml) were collected in K-EDTA microtubes within 24 to 48 hours of age through umbilical artery catheter aspiration or routine venous puncture. The samples were spun at 7000 rpm for 3 minutes. Platelet-free plasma was stored at -20°C until BNP analysis of all collected samples was carried out. The BNP assay was performed using a fully automated immunoassay system ADVIA method for the Centaur System (Bayer Diagnostic Division).
In preterm infants who were treated with indomethacin or surgical ligation we collected additional blood samples 2-4 hours before intervention and 24 hours after the completion of the ductus treatment.
Study Design
- Study Type
- Observational
- Observational Model
- Defined Population
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 24 Hours to 48 Hours (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Written parental informed consent
- •Preterm infant < 28 weeks of gestation
- •Admitted to our NICU within 48 hours after birth
Exclusion Criteria
- •No written parental informed consent,
- •Congenital heart disease,