Clinical outcomes of cervical cancer with a short intra-cavitary brachytherapy schedule involving 5 sessions of 6Gy each.

The project title is Clinical outcomes of Cervical Cancer with a short intra-cavitary brachytherapy schedule involving 5 sessions of 6Gy each.

Cervical cancer, a preventable and treatable disease, is still a leading cause of mortality among women in developing countries. As per GLOBOCAN 2020 statistics, 1,23,907 new cases were diagnosed and 77,348 lost their lives in India alone. In a locally advanced cervical cancer combined chemoradiation and brachytherapy is the standard of care treatment. Brachytherapy involves the application of a radioactive source near the tumor. It takes advantage of the inverse-square law, whereby radiation dose is inversely proportional to the square of the distance from the source. In practical terms, this allows for a very high dose to the tumor with relative sparing of the surrounding normal structures. Two applications multi fractionated Brachytherapy augments early completion of treatment which has been explored in cervical cancer, with no increase in acute or late toxicities with improved clinical outcomes in terms of local control, disease free survival, and overall survival by improving compliance and reducing overall treatment time. Individual fraction size be < 7.5Gy and the range of fractions should be 4 to 8; however, many fractionation schedules, varying from institution to institution are in use. We plan to deliver 5 sessions of 6Gy brachytherapy in two settings with a one-week gap and expect an increase in patient compliance with a reduction in overall treatment time.