Comparison of the electroencephalogram under general anesthesia with sevoflurane and desflurane, from the point of bispectral index and 95% spectral edge frequency

Not Applicable

• Conditions: Diseases requiring surgery

• Registration Number: JPRN-UMIN000021448
• Lead Sponsor: Osaka City General Hospital

Brief Summary

Both BIS and SEF95 were lower in patients receiving age-adjusted 1 MAC desflurane than those receiving 1 MAC sevoflurane.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-03-14
• Study Completion: 2016-08-20
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

Patients with (1) bronchial asthma, (2)arrhythmia, (3) psychiatric diseases or neuromuscular diseases, (4) ischemic heart diseases or decreased cardiac function with left ventricular ejection fraction equal to or less than 40%, (5) hypotension with systolic blood pressure equal to or less than 80 mmHg, (6) serum sodium levels equal to or less than 135 mEq/l; or equal to or more than 148 mEq/l

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bispectral index under general anesthesia with desflurane or sevoflurane at an end-tidal concentration of 1 MAC (minimum alveolar concentration), approximately 15-20 min following administration of desflurane or sevoflurane

Secondary Outcome Measures

Name	Time	Method
inety-five % spectral edge frequency under general anesthesia with desflurane or sevoflurane at an end-tidal concentration of 1 MAC (minimum alveolar concentration)