Study to Examine Glycaemic Responses to the Ingestion of Fruit Juices and Smoothies Using Different Measurement Methodologies.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Glycaemic indices for 5 test drinks measured using capillary blood samples
研究概览
简要总结
Glycaemic responses to carbohydrates ingested as fruit sugars may vary depending on factors inherent to the fruit and the type of sugar. The aim of this project is to investigate the glycaemic responses to a range of commercially available fruit drinks and to establish the glycaemic index for each product relative to a glucose reference. Differences in recorded responses could also be influenced by the sample type (capillary blood vs interstitial fluid) and participant characteristics. Participants will ingest 8 test drinks including 5 different fruit drinks (OJ, AJ, S&B, ENERGISE, BLUE), each matched for carbohydrate to the glucose reference (CONTROL) which will be sampled two times, an additional sample of one of the smoothies (S&B) will also be replicated. Fingerstick capillary blood sampling alongside dual sited continuous glucose monitors (CGM) will measure glucose and lactate concentrations, subjective appetite sensations will also be recorded. The tests will follow best practice guidelines for glycaemic index testing. These data will provide insight into how differing formulations can alter the glycaemic responses to fruit drinks, and whether sampling technique can affect the interpretations of measurement.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 18-65 years
- •Body mass index 18-30 kg/m2
排除标准
- •diagnosis of any form of diabetes
- •intolerances or allergies to any of the study procedures (e.g. fructose/inulin intolerance)
- •Fructose malabsorption
- •Inborn errors of fructose metabolism (e.g. fructokinase deficiency, aldolase B deficiency, fructose-1,6-bisphosphatase deficiency)
- •pregnant or lactating
- •any condition that could introduce bias to the study (e.g. diagnoses of lipid disorders, including cardiovascular disease, or therapies that alter lipid or glucose metabolism, such as statins or niacin).
研究组 & 干预措施
AJ
455 mL commercially available "Apple Juice" providing 50 g of carbohydrate [apples, ascorbic acid]. Plus 186 mL water to standardise volume
干预措施: Fruit drink (Other)
OJ
641 mL of commercially available "Smooth Orange Juice" providing 50 g of carbohydrate [100% oranges]
干预措施: Fruit drink (Other)
ENERGISE
417 mL of commercially available "Energise Super Smoothie" providing 50 g carbohydrate [apples (50%), red grapes, bananas, strawberries (10%), blackcurrants, sour cherries (3.3%), pressed beetroot, flax seeds (0.56%), guarana infusion (0.01%), vitamins B1, B2, B3, B6, C & E]. Plus 224 mL water to standardise volume
干预措施: Fruit drink (Other)
BLUE
521 mL of commercially available "Bolt from the Blue" juice drink providing 50 g carbohydrate [apple (66%), coconut water (18%), white grapes, white guava (5.2%), passion fruit, lime (0.87%), spirulina extract (0.81%) vitamins B1, B2, B3, B6, C & E]. Plus 120 mL water to standardise volume
干预措施: Fruit drink (Other)
CONTROL
50 g glucose (55 g dextrose powder accounting for hydration) plus 641 mL water
干预措施: Fruit drink (Other)
REPLICATE CONTROL
50 g glucose (55 g dextrose powder accounting for hydration) plus 641 mL water
干预措施: Fruit drink (Other)
S&B
417 mL of commercially available "Strawberries & Bananas" fruit smoothie providing 50 g carbohydrate [strawberries (31%), apples, bananas (22%), white grapes, oranges, blackcurrants]. Plus 224 mL water to standardise volume
干预措施: Fruit drink (Other)
REPLICATE S&B
417 mL of commercially available "Strawberries & Bananas" fruit smoothie providing 50 g carbohydrate [strawberries (31%), apples, bananas (22%), white grapes, oranges, blackcurrants]. Plus 224 mL water to standardise volume
干预措施: Fruit drink (Other)
结局指标
主要结局
Glycaemic indices for 5 test drinks measured using capillary blood samples
时间窗: 120 minutes
Glycaemic indices \[2-hour incremental area under the glucose curve (mmol/L-1x120 minutes) for each of the 5 test drinks relative to mean value of control conditions (CONTROL, REPLICATE CONTROL), expressed as a percentage\] in capillary blood samples
次要结局
- Glycaemic index of all conditions with capillary blood samples vs CGM(120 minutes)
研究者
Emma Greatorex Brooks
PhD Researcher
University of Bath