Nitrocamptothecin in Treating Patients With Metastatic Cancer of the Urinary Tract
- Conditions
- Bladder CancerTransitional Cell Cancer of the Renal Pelvis and UreterUrethral Cancer
- Registration Number
- NCT00006026
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of nitrocamptothecin in treating patients who have metastatic cancer of the urinary tract.
- Detailed Description
OBJECTIVES: I. Determine the objective response to nitrocamptothecin in patients with metastatic urothelial tract tumors. II. Determine the response rate in these patients when treated with this regimen. III. Determine the duration of objective response in these patients when treated with this regimen. IV. Characterize the toxicities of this treatment in this patient population.
OUTLINE: This is a multicenter study. Patients receive oral nitrocamptothecin daily on days 1-5. Treatment continues weekly every 3 weeks for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 6 weeks until disease progression.
PROJECTED ACCRUAL: A total of 14-25 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (11)
Centre de Lute Contre le Cancer,Georges-Francois Leclerc
🇫🇷Dijon, France
Azienda Ospedaliera di Padova
🇮🇹Padova (Padua), Italy
Centre Henri Becquerel
🇫🇷Rouen, France
Ospedale San Giovanni
🇨ðŸ‡Bellinzona, Switzerland
Rotterdam Cancer Institute
🇳🇱Rotterdam, Netherlands
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
CRLCC Nantes - Atlantique
🇫🇷Nantes-Saint Herblain, France
Rambam Medical Center
🇮🇱Haifa, Israel
U.Z. Gasthuisberg
🇧🇪Leuven, Belgium
Centre Jean Perrin
🇫🇷Clermont-Ferrand, France
Clinique De Genolier
🇨ðŸ‡Genolier, Switzerland