Ultrasonic measurement of optic nerve sheath diameter in prolonged abdominal surgery (UMONDStudy).
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Perioperative variation of optic nerve sheath diameter
研究概览
简要总结
•Prolonged abdominal surgery incurs large amount of blood loss, rapid fluid replacement and fluid shifts across physiological barriers causing tissue edema and raised ICP.
•Added conditions such as- pneumoperitonium, trendelenberg position increase ICP further.
•Raised ICP is reflected in Optic nerve sheath diameter (ONSD) as the ON is surrounded by dural sheath and increased CSF pressure causes the sheath to swell.
ONSD measured at 3 mm below the optic disc using a high frequency linear ultrasound transducer (UST) is
•Safe, reliable, >90% accuracy
•Can be performed by any anaesthesiologist with some training in point of care ultrasound (POCUS).
The primary objective of the study is to develop a model which can predict the change in ONSD after surgery based on various clinical and intraoperative parameters. We will model the difference in OND using a linear regression model with prespecified parameters, mainly-
1.Prolonged duration
2.Trendelenberg position (head down)
3.Pneumoperitonium (laparoscopy)
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Abdominal surgery lasting for more than 4 hours.
排除标准
- •Known retinal disease Known optic disease.
结局指标
主要结局
Perioperative variation of optic nerve sheath diameter
时间窗: Measurement of optic nerve sheath diameter preoperatively and postoperatively before extubation/ in ICU in case if Patient is shifted intubated to icu
次要结局
- Conjunctival edema associated? yes/ no(before and at the end of surgery)