Efficacy of antimalaria drug for the treatment of malaria

Not Applicable

• Conditions: Malaria

• Registration Number: PACTR202309773069812
• Lead Sponsor: niversity of Gondar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-07-06
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

•Age 6 months–70 years
•No history of malaria treatment within the last 28 days
•Permanent resident within 5 km radius from the HC
•Plasmodium falciparum infection confirmed by microscopy
•Parasitaemia level of 1,000/µl-100,000/µl asexual forms
•Presence of axillary temperature = 37.5 °C or history of fever during the past 24hs
•Ability to swallow oral medication
•Ability to comply to the study protocol

Exclusion Criteria

•Presence of complication or danger signs of severe malaria
•Presence of severe malnutrition (body mass index (BMI) <18.5 kg/m2 or z-score <3)
•Presence of known diseases other than malaria (typhoid fever, typhus, hepatitis, HIV/AIDS, pneumonia and tuberculosis)
•Regular medications that may interfere with AL pharmacokinetics (antiretroviral, ketoconazole and rifampicin)
•History of hypersensitivity reactions to AL
•Pregnancy or lactating women
•Vomited twice during drug administration

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
adequate clinical and parasitological response

Secondary Outcome Measures

Name	Time	Method
Asexual parasitaemia and fever clearance