PACTR202309773069812已完成Unknown
Therapeutic efficacy and safety of Artemether-Lumefantrine combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria at Teda Health Center, Northwest Ethiopia
niversity of Gondar0 个研究点目标入组 88 人开始时间: 2023年7月6日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 已完成
- 发起方
- 入组人数
- 88
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 0 Month(s) 至 23 Month(s)（—）
- 性别
- All
入选标准
- •Age 6 months–70 years
- •No history of malaria treatment within the last 28 days
- •Permanent resident within 5 km radius from the HC
- •Plasmodium falciparum infection confirmed by microscopy
- •Parasitaemia level of 1,000/µl-100,000/µl asexual forms
- •Presence of axillary temperature = 37.5 °C or history of fever during the past 24hs
- •Ability to swallow oral medication
- •Ability to comply to the study protocol
排除标准
- •Presence of complication or danger signs of severe malaria
- •Presence of severe malnutrition (body mass index (BMI) <18.5 kg/m2 or z-score <3)
- •Presence of known diseases other than malaria (typhoid fever, typhus, hepatitis, HIV/AIDS, pneumonia and tuberculosis)
- •Regular medications that may interfere with AL pharmacokinetics (antiretroviral, ketoconazole and rifampicin)
- •History of hypersensitivity reactions to AL
- •Pregnancy or lactating women
- •Vomited twice during drug administration
研究者
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