Comparative Evaluation of the Effects of Injectable Platelet Rich Fibrin(i-PRF) on Rate of Maxillary Canine Retraction – A Split Mouth Randomized Trial

A split-mouth, randomized controlled trial will be conducted using a single-center, single-blinded (outcome assessor), parallel, double-arm design with a 1:1 allocation ratio. A total of 20 patients undergoing fixed appliance therapy who meet the inclusion and exclusion criteria will be recruited for the study. In the experimental group, 2 ml of injectable platelet-rich fibrin (i-PRF) will be infiltrated into the buccal submucosa, and 1 ml of i-PRF will be infiltrated into the palatal submucosa. No i-PRF injection will be administered in the control group. The rate of canine retraction will be assessed and compared between both the groups at three time points: T0 (baseline), T1 (after 1 month), and T2 ( after 2 months). Additionally, three-dimensional control (transverse, sagittal, and vertical), as well as gingival and periodontal health of the canine and molar teeth, will be evaluated and compared using the Plaque Index, Gingival Index, Modified Sulcular Bleeding Index, and Pocket Depth at T0, T1, and T2. The data will be analyzed using appropriate statistical analysis.