Dual antiplatelet therapy in the acute phase following stroke and TIA; which is the best regimen?
Phase 1
- Conditions
- Symptomatic carotid artery stenosisMedDRA version: 9.1 Level: LLT Classification code 10007687 Term: Carotid artery stenosis
- Registration Number
- EUCTR2007-002681-34-GB
- Lead Sponsor
- St Georges Healthcare NHS Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients with greater than or equal to 50% carotid artery stenosis AND symptoms of transient ischaemic attack or stroke within the last month.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
1. antiplatelet/antithrombotic medication other than aspirin (although low does prophylactic subcutaneous heparin for DVT prophylaxis will be allowed)
2. patients with prosthetic heart valves who have gaseous embolic signals.
3. patients in who clopidogrel or dipyridamole are contraindicated.
4. If carotid endarterectomy is planned during the study.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Is clopidogrel plus aspirin, or dipyridamole slow release plus aspirin, a better combination in preventing embolisation in recently symptomatic large artery atherosclerotic disease?;Secondary Objective: ;Primary end point(s): Number of embolic signals during transcranial Doppler recording from ipsilateral middle cerebral artery performed at 48 hours after study entry
- Secondary Outcome Measures
Name Time Method